108673-17-2

Basic information

• Product Name: Ethanone, 1-[4-[(1R)-1-hydroxyethyl]phenyl]- (9CI)
• Synonyms: Ethanone, 1-[4-[(1R)-1-hydroxyethyl]phenyl]- (9CI)
• CAS NO: 108673-17-2
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• Product Categories: ACETYLGROUP
• Mol File: 108673-17-2.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 302.7±17.0 °C(Predicted)
• Appearance: /
• Density: 1.080±0.06 g/cm3(Predicted)
• PKA: 14.00±0.20(Predicted)
• CAS DataBase Reference: Ethanone, 1-[4-[(1R)-1-hydroxyethyl]phenyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-[(1R)-1-hydroxyethyl]phenyl]- (9CI)(108673-17-2)
• EPA Substance Registry System: Ethanone, 1-[4-[(1R)-1-hydroxyethyl]phenyl]- (9CI)(108673-17-2)

Safety Data

• Hazardous Substances Data: 108673-17-2(Hazardous Substances Data)

Upstream product

• 1009-61-6 1,4-Diacetylbenzene 
• 3457-45-2 p-formylacetophenone 
• 75-16-1 methylmagnesium bromide 
• 143329-79-7 meso-α,α’-dimethyl-(1,4-benzene)dimethanol monoacetate 
• 6781-43-7 1,4-bis(1-hydroxyethyl)benzene 
• 937-30-4 4-ethylacetophenone 
• 99-90-1 para-bromoacetophenone 
• 4360-68-3 2-(4-bromophenyl)-2-methyl-1,3-dioxolane 
• 329006-00-0 2-[4-(1-hydroxyethyl)phenyl]-2-methyl-1,3-dioxolane 
• 112710-41-5 meso-α,α’-dimethyl-(1,4-benzene)dimethanol 
• 909295-66-5 1-[(R)-1-(isobutyryloxy)ethyl]-4-[(S)-1-hydroxyethyl]benzene 
• 105752-35-0 1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethanone 
• 105-05-5 1,4-diethylbenzene 
• 103966-60-5 1-(α-acetoxyethyl)-4-ethylbenzene 

Downstream Products

• 185144-39-2 (R)-4'-(1-acetyloxyethyl)acetophenone 
• 185144-38-1 (S)-1-(4-(1-hydroxyethyl)phenyl)ethanone 
• 105-06-6 1,4-Divinylbenzene 
• 10537-63-0 1-(4-vinylphenyl)ethanone 
• 1009-61-6 1,4-Diacetylbenzene 
• 6781-43-7 1,4-bis(1-hydroxyethyl)benzene 
• 329006-04-4 2-(1-(4-acetylphenyl)ethyloxy)-1,3,2-dioxaphosphorinane 
• 823790-71-2 N-acetyl-1-(4'-acetylphenyl)ethenamine 

Relevant articles and documents

Bifunctional rhenium complexes for the catalytic transfer-hydrogenation reactions of ketones and imines

The silyloxycyclopentadienyl hydride complexes [Re(H)(NO)(PR 3)(C5H4OSiMe2tBu)] (R=iPr (3a), Cy (3b)) were obtained by the reaction of [Re(H)(Br)(NO)(PR3) 2] (R=iPr, Cy) with Li[C5H4OSiMe 2tBu]. The ligand-metal bifunctional rhenium catalysts [Re(H)(NO)(PR3)(C5H4OH)] (R=iPr (5a), Cy (5b)) were prepared from compounds 3a and 3b by silyl deprotection with TBAF and subsequent acidification of the intermediate salts [Re(H)(NO)(PR 3)(C5H4O)][NBu4] (R=iPr (4a), Cy (4b)) with NH4Br. In nonpolar solvents, compounds 5a and 5b formed an equilibrium with the isomerized trans-dihydride cyclopentadienone species [Re(H)2(NO)(PR3)(C5H4O)] (6a,b). Deuterium-labeling studies of compounds 5a and 5b with D2 and D 2O showed H/D exchange at the HRe and HO positions. Compounds 5a and 5b were active catalysts in the transfer hydrogenation reactions of ketones and imines with 2-propanol as both the solvent and H2 source. The mechanism of the transfer hydrogenation and isomerization reactions was supported by DFT calculations, which suggested a secondary-coordination-sphere mechanism for the transfer hydrogenation of ketones. The Re-al deal: Bifunctional rhenium complexes [Re(H)(NO)(PR 3)(C5H4OH)] (R=Cy, iPr) of Shvo-type were prepared and used as catalysts for the transfer hydrogenation of ketones and imines. TOFs up to 1164 h-1 were obtained for ketones and up to 79 h-1 for imines. DFT calculations suggested a secondary-coordination- sphere mechanism for the transfer hydrogenation of ketones.

Novel non-metal catalyst for catalyzing asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone

The invention discloses a novel non-metal catalyst for catalyzing asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone. The preparation method of a chiral alcohol compound shown as formula IV comprises the following step of: reacting a ketone compound shown as formula V with hydrogen under the catalysis of tri(4-hydrotetrafluorophenyl)boron and a chiral oxazoline compound to obtain the chiral alcohol compound shown as the formula IV; the preparation method of a chiral tetralone compound shown as formula VI comprises the following step of: under the catalysis of tri(4-hydrotetrafluorophenyl)boron and a chiral oxazoline compound, reacting an alpha, beta-unsaturated ketone compound shown as formula VII with hydrogen to obtain the chiral tetralone compound shown as the formula VI. The method has the advantages of easy synthesis of raw materials, mild reaction conditions, simple operation, high stereoselectivity and the like, the ee value of the product is up to 92%, and the yield is up to 99%.

Asymmetric Hydrogenation of Ketones and Enones with Chiral Lewis Base Derived Frustrated Lewis Pairs

The concept of frustrated Lewis pairs (FLPs) has been widely applied in various research areas, and metal-free hydrogenation undoubtedly belongs to the most significant and successful ones. In the past decade, great efforts have been devoted to the synthesis of chiral boron Lewis acids. In a sharp contrast, chiral Lewis base derived FLPs have rarely been disclosed for the asymmetric hydrogenation. In this work, a novel type of chiral FLP was developed by simple combination of chiral oxazoline Lewis bases with achiral boron Lewis acids, thus providing a promising new direction for the development of chiral FLPs in the future. These chiral FLPs proved to be highly effective for the asymmetric hydrogenation of ketones, enones, and chromones, giving the corresponding products in high yields with up to 95 % ee. Mechanistic studies suggest that the hydrogen transfer to simple ketones likely proceeds in a concerted manner.