108686-20-0Relevant academic research and scientific papers
A short, gram-scale synthesis of 2,5-disubstituted furans
Chang, Stanley,Desai, Saheena,Leznoff, Daniel B.,Merbouh, Nabyl,Britton, Robert
, p. 3219 - 3222 (2013)
A modified Feist-Benary furan synthesis has been developed that involves a lithium aldol reaction between a methyl ketone and an α-chloroaldehyde followed by a thermally induced tetrahydrofuran formation/dehydration sequence and affords 2,5-disubstituted
One-Pot Synthesis of Substituted Homoallylic Alcohols (3-Alkenols) and 1-Deuterio-3-alkenols; II. Extension to Ketone Enolates
Barluenga, Jose,Alvarez, Flora,Concellon, Jose M.,Bernad, Pablo,Yus, Miguel
, p. 318 - 320 (2007/10/02)
The reaction of different lithium ketone enolates with α-chloro carbonyl compounds followed by in situ reduction with lithium aluminium hydride or deuteride and final lithiation with lithium powder leads to the corresponding homoallylic or 1-deuterio homoallylic alcohols in a regioselective manner.
SYNTHESIS OF HOMOALLYLIC ALCOHOLS. PART 3. GENERALIZATION TO THE USE OF ESTER ENOLATES AND GRIGNARD REAGENTS AS NUCLEOPHILES
Barluenga, Jose,Alvarez, Flora,Concellon, Jose M.,Yus, Miguel
, p. 3265 - 3285 (2007/10/02)
The successive treatment of different α-chloro carbonyl compounds (1) with a lithium ester enolate (6), lithium aluminium hydride or deuteride and final lithiation with lithium powder leads, after acid hydrolysis, to the corresponding homoallylic alcohols
