108763-41-3Relevant academic research and scientific papers
Ring size changes in the development of class I HDAC inhibitors
Cho, Er-Chieh,Liu, Chi-Yuan,Tang, Di-Wei,Lee, Hsueh-Yun
, p. 1387 - 1401 (2021/07/06)
Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.
INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS
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Page/Page column 42-43, (2009/05/30)
There is provided according to the invention novel compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: (I) useful as PPAR activators.
Asymmetric total synthesis of martinelline and martinellic acid
Ikeda, Shuhei,Shibuya, Masatoshi,Iwabuchi, Yoshiharu
, p. 504 - 506 (2007/10/03)
Herein, we describe the first asymmetric total synthesis of (-)-martinelline ((-)-2) and the second total synthesis of (-)-martinellic acid ((-)-1) by employing a tandem Mukaiyama-Mannich reaction/aminal cyclization as the key step. The Royal Society of C
BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE
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Page/Page column 85; 124-125, (2008/06/13)
Disclosed are compounds, compositions and methods for treatingFlaviviridae family virus infections.
2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
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, (2008/06/13)
2-Phenylbenzimidazoles and 2-phenylindoles of formula I wherein A is N or CH, R1is hydrogen or alkyl which optionally carries an OR11group, R11is hydrogen or alkyl, R2is hydrogen, chlorine, fluorine, bromine, iodine, alkyl, nitro, CF3, CN, NR21R22, NH—CO—R23, OR21, R21and R22are each hydrogen or alkyl, R23is hydrogen, alkyl or phenyl, R3is —(CH2)q—NR31R32, q is 0, 1, 2 or 3, R31is hydrogen, alkyl, (CH2)rNR33R34, R32is (CH2)rNR33R34, r is 2, 3, 4, 5 or 6, R33and R34are each hydrogen, alkyl or phenylalkyl wherein the phenyl ring is optionally substituted, or R33and R34and the nitrogen atom form a 3- to 8-membered ring, R4is hydrogen, alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH—CO—R43, OR41, R41and R42are each hydrogen or alkyl, and R43is alkyl or phenyl, are useful as inhibitors of poly(ADP-ribose)polymerase and for the production of drugs.
Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: Synthesis and evaluation of a new series of indole derivatives
Kamiya,Matsui,Shirahase,Nakamura,Wada,Kanda,Shimaji,Kakeya
, p. 1692 - 1695 (2007/10/03)
A novel series of N-substituted 3-(1H-imidazol-1-ylmethyl)indole carboxylic acid derivatives were prepared and evaluated for thromboxane A2 (TXA2) synthetase-inhibitory and histaminergic H1-blocking activity. Among the compounds synthesized, indole-6-carboxylic acid derivatives showed higher activities than the other positional isomers of carboxylic acid. 1-[3-(4- Benzhydryl-1-piperazinyl)propyl]-3-(1H-imidazol-1-ylmethyl)-1H-indole-6- carboxylic acid (12) had the strongest thromboxane synthetase inhibitory activity (IC50 = 5 x 10-8 M) and H1-blocking activity (IC50 = 8 x 10- 9 M).
A MILD METHOD FOR THE CONVERSION OF ACTIVATED ARYL METHYL GROUPS TO CARBOXALDEHYDES VIA THE UNCATALYZED PERIODATE CLEAVAGE OF ANAMINES
Vetelino, Michael G.,Coe, Jotham W.
, p. 219 - 222 (2007/10/02)
A mild procedure for the oxidative cleavage of aryl enamines to aryl aldehydes by periodate without the need for transition metal catalysis is presented.
Alpha-aminoacyl-penicillins and cephalosporins
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, (2008/06/13)
Antibacterially active and animal growth-regulating novel β-lactam compounds of the formula STR1 in which R1 represents an optionally substituted radical of the formula STR2 Z represents oxygen, sulphur or --N--R13, and A represents
