438003-09-9Relevant academic research and scientific papers
Ring size changes in the development of class I HDAC inhibitors
Cho, Er-Chieh,Liu, Chi-Yuan,Tang, Di-Wei,Lee, Hsueh-Yun
, p. 1387 - 1401 (2021/07/06)
Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.
INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS
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Page/Page column 43, (2009/05/30)
There is provided according to the invention novel compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: (I) useful as PPAR activators.
Method for inhibiting neoplastic cells with indole derivatives
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, (2008/06/13)
A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.
