35086-87-4

Basic information

• Product Name: (E)-2-METHYL-3-PHENYL-ACRYLOYL CHLORIDE
• Synonyms: 2-METHYL-3-PHENYLPROP-2-ENOYL CHLORIDE;(E)-2-METHYL-3-PHENYL-ACRYLOYL CHLORIDE;2-METHYL-3-PHENYLACRYLOYL CHLORIDE
• CAS NO: 35086-87-4
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.63
• Mol File: 35086-87-4.mol
• Article Data: 54

Chemical Properties

• Melting Point: 24-26°C
• Boiling Point: 266.6°C at 760 mmHg
• Flash Point: 117.6°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 0.00858mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: (E)-2-METHYL-3-PHENYL-ACRYLOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-METHYL-3-PHENYL-ACRYLOYL CHLORIDE(35086-87-4)
• EPA Substance Registry System: (E)-2-METHYL-3-PHENYL-ACRYLOYL CHLORIDE(35086-87-4)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• Hazardous Substances Data: 35086-87-4(Hazardous Substances Data)

Usage

General Description

(E)-2-Methyl-3-phenyl-acryloyl chloride, also known by its IUPAC name 2-chloro-3-phenylprop-2-enoyl chloride, is a chemical compound with the formula C10H9ClO. It is a colorless to light yellow liquid with a pungent odor, and is primarily used in the synthesis of pharmaceutical and agrochemical products. The compound is a key intermediate in the production of various pharmaceuticals, including anti-cancer drugs and antihistamines. It also has applications in the production of perfumes and other fine chemicals. Due to its acryloyl functionality, it is a useful building block for the creation of polymers and materials with specific properties. (E)-2-Methyl-3-phenyl-acryloyl chloride is a potentially hazardous chemical and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C10H9ClO/c1-8(10(11)12)7-9-5-3-2-4-6-9/h2-7H,1H3/b8-7+

Upstream product

• 7042-33-3 ethyl (E)-2-methyl-3-phenyl-2-propenoate 
• 100-52-7 benzaldehyde 
• 1199-77-5 α-methylcinnamic acid 
• 704-80-3 (E)-3-phenyl-2-butenoic acid 
• 1895-97-2 2-methyl-3-phenylacrylic acid 
• 100-44-7 benzyl chloride 

Downstream Products

• 49659-72-5 2-((E)-2-Methyl-3-phenyl-acryloylamino)-3-phenyl-propionic acid 
• 613672-50-7 N-isobutyryl-2-methyl-3-phenyl-2-propenimide 
• 952198-19-5 1-benzyl-5,5-dimethyl-((E)-2-methyl-3-phenylpropenoyl)-pyrazolidin-3-one 
• 934192-59-3 dithiocarbonic acid S-[3-(acetyl-allyl-amino)-2-methyl-3-oxo-1-phenyl-propyl] ester O-ethyl ester 
• 2177-47-1 2-Methylindene 
• 131214-21-6 (E)-2-methyl-3-phenylacrylamide 
• 53587-72-7 (E)-2-methyl-3-phenylacrylonitrile 
• 405506-53-8 (E)-1-chloro-3-methyl-4-phenyl-1-(phenylsulfinyl)but-3-ene-2-one 
• 940-27-2 N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride 
• 136057-73-3 -4-(1-methylethyl)-3-(2-methyl-1-oxo-3-phenyl-2-propenyl)-2-oxazolidinone 
• 77302-25-1 (E)-N-allyl-2-methyl-3-phenylacrylamide 

Relevant articles and documents

Catalytic Enantioselective Synthesis of 3,4-Polyfused Oxindoles with Quaternary All-Carbon Stereocenters: A Rh-Catalyzed C-C Activation Approach

The first Rh-catalyzed enantioselective synthesis of a 3,4-polyfused oxindole ring system enabled by carboacylation of acrylic amides based on C-C activation is reported. This transformation provides a new entry to access 3,4-polyfused oxindoles bearing q

Photoredox Cyclization of N-Arylacrylamides for Synthesis of Dihydroquinolinones

Metal- and additive-free photoredox cyclization of N-arylacrylamides is herein reported that provides a concise access to the formation of dihydroquinolinones. In this protocol, sustainable visible light was used as the energy source, and the organic light-emitting molecule 4CzIPN served as the efficient photocatalyst. This reaction system features exclusive 6-endo-trig cyclization selectivity with a generally good yield of a range of functionalized dihydroquinolinones and dihydrobenzoquinolinones. Mechanistical studies reveal the feasibility of both 1,3-H shift and intersystem crossing of the diradical intermediate.

Synthesis method and applications of N heteroatom polysubstituted benzoquaternary cycloketone

The invention discloses an N heteroatom polysubstituted benzoquaternary cycloketone synthesis method. According to the invention, the synthetic route starts from a known aniline compound A, the hundred g-scale preparation can be achieved, the yield can ac

Copper-Photocatalyzed Contra-Thermodynamic Isomerization of Polarized Alkenes

The contra-thermodynamic isomerization of α- and β-substituted cinnamate derivatives catalyzed by the Cu(OAc)2/rac-BINAP complex under blue light irradiation is reported. The use of an oxazolidinone template, which favored the complexation of the copper catalyst to the substrate, allowed the E → Z isomerization of the catalytically formed chromophore under simple and robust reaction conditions in good to excellent ratios. The mechanism of this process based on the transient formation of a chromophore was also studied.