1088979-71-8Relevant academic research and scientific papers
COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS
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Page/Page column 86; 87, (2015/03/28)
The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.
PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES
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Page/Page column 273; 274, (2010/12/29)
This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.
New gas-phase cascade reactions of stabilized phosphorus ylides leading to ring-fused indoles and to quinolines
Aitken, R. Alan,Murray, Lorna
supporting information; experimental part, p. 9781 - 9783 (2009/04/06)
(Chemical Equation Presented) Gas-phase cyclization processes of stabilized phosphorus ylides bearing a suitably substituted 2-aminophenyl group lead efficiently either to 3-substituted quinolines or benzo[c]-carbazole and heterocyclic-fused analogues depending on the substituents present.
