716-41-6Relevant academic research and scientific papers
Synthesis, X-ray crystal and monoamine oxidase inhibitory activity of 4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine 5,5-dioxides: In vitro studies and docking analysis
Ahmad, Shakeel,Jalil, Saquib,Zaib, Sumera,Aslam, Sana,Ahmad, Matloob,Rasul, Azhar,Arshad, Muhammad Nadeem,Sultan, Sadia,Hameed, Abdul,Asiri, Abdullah M.,Iqbal, Jamshed
, p. 9 - 22 (2019/02/12)
We report the synthesis and biological evaluation of two new series of 2-amino-6-benzyl-4-phenyl-4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine-3?carbonitrile 5,5-dioxides and 2-amino-6-methyl-4-phenyl-4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine-3?carbon
Synthesis, characterization, monoamine oxidase inhibition, molecular docking and dynamic simulations of novel 2,1-benzothiazine-2,2-dioxide derivatives
Ahmad, Shakeel,Zaib, Sumera,Jalil, Saquib,Shafiq, Muhammad,Ahmad, Matloob,Sultan, Sadia,Iqbal, Mazhar,Aslam, Sana,Iqbal, Jamshed
, p. 498 - 510 (2018/07/13)
In this research work, we report the synthesis and biological evaluation of two new series of 1-benzyl-4-(benzylidenehydrazono)-3,4-dihydro-1H-benzo[c] [1,2]thiazine 2,2-dioxides and 1-benzyl-4-((1-phenylethylidene)hydrazono)-3,4-dihydro-1H-benzo[c][1,2]t
4 - hydroxy - 3 - benzoyl - 1 - alkyl - 2, 1 - benzothiazine - 2, 2 - dioxide derivative and application thereof
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Paragraph 0009; 0015; 0016, (2017/08/14)
The invention relates to a 4-hydroxy-3-benzoyl-1-alkyl-2, 1-benzothiazine-2, 2-dioxide derivative and application. The structure general formula of the compound is (I), and R1 and R2 are defined according to the claim. 2-methyl anthranilate is used as raw
4 - hydroxy - 3 - acyl - 1 - alkyl - 2, 1 - benzothiazine - 2, 2 - dioxide derivative and application thereof
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Paragraph 0008; 0015, (2017/08/25)
The invention relates to a 4-hydroxy-3-acyl-1-alkyl-2,1-benzothiazine-2,2-dioxide ramification and application thereof. The 4-hydroxy-3-acyl-1-alkane-2,1-benzothiazine-2,2-dioxide derivative is obtained through sulfoamidation, alkylation, ring closure and
Discovery of (2-benzoylethen-1-ol)-containing 1,2-benzothiazine derivatives as novel 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting-based herbicide lead compounds
Lei, Kang,Hua, Xue-Wen,Tao, Yuan-Yuan,Liu, Yang,Liu, Na,Ma, Yi,Li, Yong-Hong,Xu, Xiao-Hua,Kong, Chui-Hua
supporting information, p. 92 - 103 (2015/12/31)
A series of (2-benzoylethen-1-ol)-containing benzothiazine derivatives was synthesized, and their herbicidal activities were first evaluated. The bioassay results indicated that some of 3-benzoyl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide derivatives displayed good herbicidal activity in greenhouse testing, especially, compound 4w had good pre-emergent herbicidal activities against Brassica campestris, Amaranthus retroflexus and Echinochloa crusgalli even at a dosage of 187.5 g ha-1. More importantly, compound 4w displayed significant inhibitory activity against Arabidopsis thaliana HPPD and was identified as the most potent candidate with IC50 value of 0.48 μM, which is better than the commercial herbicide sulctrione (IC50 = 0.53 μM) and comparable with the commercial herbicide mesotrione (IC50 = 0.25 μM). The structure-activity relationships was studied and provided some useful information for improving herbicidal activity. The present work indicated that (2-benzoylethen-1-ol)-containing 1,2-benzothiazine motif could be a potential lead structure for further development of novel HPPD inhibiting-based herbicides.
COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS
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Page/Page column 85, (2015/03/28)
The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.
Synthesis, characterization and biological activities of 2-[(methyl sulfonyl)]amino benzoic acid derivatives and their metal complexes
Bokhari, Tanveer Hussain,Ashraf, Naveeda,Shafiq, Muhammad,Ahmed, Matloob,Rasool, Nasir,Shad, Hazoor Ahmad,Ashraf, Nabeela,Arshad, Nadeem,Tahir, Muhammad Nawaz
, p. 1326 - 1330 (2015/02/19)
Sulfonamide derivatives and their metal complexes are acknowledged pharmaceutical moieties because this group has been played the key role as a functional part of the most of the drug structures due to constancy and for bearance in human beings. Sulfonamides have endowed great biological potential such as antibacterial, insulin releasing, carbonic anhydrase inhibitory, anti-inflammatory, antifungal and antitumor activities. In the present work, 2-[(methyl sulfonyl)] amino benzoic acid was N-alkylated using alkylating agent such as methyl. Due to the presence of electron donating groups like, -COOH, -SO2, N-, the above mentioned molecules act as an excellent chelating agent. These substituted N-alkylated sulfonamide ligands were treated with a number of outer and inner transition metals such as Co(II), Cu(II), Ce(II), Pr(II), Dy(II) and Nd(II) to form coordinate complexes. These newly synthesized sulfonamides and their metal complexes were characterized by melting points, solubility, colour, FTIR analysis and XRD. These products were subjected for antimicrobial activities as well as other accessible applications.
The effect of hydrogen bond on Br?nsted acid-catalyzed intramolecular hydroamination of unfunctionalized olefins
Li, Ting-Ting,Liu, Gong-Qing,Wang, Yu-Mei,Cui, Bin,Sun, Hui,Li, Yue-Ming
supporting information, p. 7003 - 7009 (2015/08/19)
The catalytic activity of benzoic acid could be increased by introducing a hydrogen bond donor group at the ortho-position. Preliminary DFT calculation indicated that the activation of CC double bond was realized by the action of both the carboxyl group and the hydrogen bond donor. The amino group was brought to the activated CC bond by the interaction between the carboxyl oxygen and amino proton. This interaction also increased the nucleophilicity of the amino group. Thus, in the presence of 20 mol % of 2-(trifluoromethanesulfonamido)benzoic acid, intramolecular hydroamination of unfunctionalized olefins gave the corresponding products in up to 95% isolated yields.
Mild hypervalent iodine mediated oxidative nitration of N-aryl sulfonamides
Kloeckner, Ulrich,Nachtsheim, Boris J.
supporting information, p. 10485 - 10487 (2014/09/29)
An oxidative and acid-free method for the nitration of N-aryl sulfonamides has been developed using a combination of sodium nitrite as cheap and easy to handle NO2-source and the hypervalent iodine reagent PIFA as stoichiometric oxidant. Under
An efficient, three-component synthesis and molecular structure of derivatives of 2-amino-3-R-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide spirocombined with a 2-oxindole nucleus
Shemchuk, Leonid A.,Lega, Dmitry A.,Redkin, Ruslan Gr.,Chernykh, Valentin P.,Shishkin, Oleg V.,Shishkina, Svetlana V.
, p. 8348 - 8353 (2015/03/03)
Spiro[(2-amino-3-R-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide)-4,3′-(1′-R′-5′-R″-indolin-2′-one)] compounds were synthesized based on the three-component interaction of benzo[c][2,1]thiazin-4-on 2,2-dioxide with corresponding isatins a
