109012-81-9

Basic information

• Product Name: methyl 2-methoxycarbonyl-3-phenyl-5-oxohexanoate
• Synonyms: methyl 2-methoxycarbonyl-3-phenyl-5-oxohexanoate
• CAS NO: 109012-81-9
• Molecular Weight: 278.305
• Mol File: 109012-81-9.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: methyl 2-methoxycarbonyl-3-phenyl-5-oxohexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-methoxycarbonyl-3-phenyl-5-oxohexanoate(109012-81-9)
• EPA Substance Registry System: methyl 2-methoxycarbonyl-3-phenyl-5-oxohexanoate(109012-81-9)

Safety Data

• Hazardous Substances Data: 109012-81-9(Hazardous Substances Data)

Upstream product

• 122-57-6 1-Phenylbut-1-en-3-one 
• 108-59-8 malonic acid dimethyl ester 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 1896-62-4 (E)-benzalacetone 
• 186581-53-3 diazomethane 
• 4354-90-9 (3-oxo-1-phenyl-butyl)-malonic acid 
• 500055-91-4 cyano-2 phenyl-3 oxo-5 hexanoate de methyle 

Downstream Products

• 211818-69-8 methyl(E)-2-methoxycarbonyl-5-methylsulfonyloxyimino-3-phenylhexanoate 
• 146497-71-4 methyl 2-hydroxy-4-oxo-6-phenylcyclohex-2-enecarboxylate 
• 4354-90-9 (3-oxo-1-phenyl-butyl)-malonic acid 

Relevant articles and documents

Solvent-Free Enantioselective Michael Reactions Catalyzed by a Calixarene-Based Primary Amine Thiourea

An upper-rim functionalized calix[4]arene-based thiourea installed onto the (R,R)-1,2-cyclohexanediamine scaffold was synthesized with a view to investigate its catalytic ability in enantioselective Michael additions. The reactions were found to conveniently proceed under solvent-free conditions, observing good to high enantioselectivities. From this preliminary study, the calix[4]arene unit is likely to play a role in affecting the conversion and to a lesser extent to the stereochemical outcome of the reactions through van der Waals contacts and C-H···π interactions with the substrates.

Asymmetric organocatalytic conjugate addition of malonates to enones using a proline tetrazole catalyst

5-Pyrrolidin-2-yltetrazole performs as a useful organocatalyst for the asymmetric addition of malonates to a range of enones, with good to excellent enantioselectivities. The Royal Society of Chemistry 2006.

Enantioselective synthesis of 2,4,5-trisubstituted tetrahydropyrans via peptide-catalyzed michael addition followed by Kishi's reductive cyclization

An enantioselective synthesis of 2,4,5-trisubstituted tetrahydropyrans has been achieved in four steps from α,β-unsaturated ketones and dimethyl malonate by peptide-catalyzed asymmetric Michael addition and diastereoselective construction of tetrahydropyr

A kind of T-leucine derivative of the chiral amine compound and its preparation method and application

The invention discloses a tertiary leucine derived chiral amine compound as well as a preparation method and application thereof. The chiral amine compound contains a tert-butyl group, a primary amine, a secondary amine or a tertiary amine functional group and has the structural formula as shown in the specification; and chiral amine and salts thereof are prepared through simple preparation steps by taking common tert-leucine as the raw material to form the chiral amine compound. The chiral amine and the salts thereof can be used for the asymmetrical Michael additive reaction between alpha, beta-unsaturated ketone and a nucleophilic reagent such as nitrocarbol, malonic ester, substituted oxazolone and the like and the asymmetrical cascade reaction between the alpha, beta-unsaturated ketone and fifth-position unsaturated rhodanine, between fifth-position unsaturated hydantoin and the alpha, beta-unsaturated ketone; and the tertiary leucine derived chiral amine compound has very high catalytic activity and stereoselectivity as well as the highest diastereoselectivity of 30/1 and the highest enantioselectivity of 99%, and is wide in oligomer range.