109013-56-1Relevant academic research and scientific papers
Synthesis and Characterization of a Series of Orthogonally Protected l-Carnosine Derivatives
El-Dakdouki, Mohammad H.,Daouk, Nadine,Abdallah, Hiba
, p. 1 - 12 (2018/02/19)
l-Carnosine (β-alanyl-l-histidine) is an endogenous dipeptide that has been recognized for its broad spectrum of beneficial biological activities. However, the therapeutic utility of molecule has been hampered by its instability in human plasma (half-life
The first total synthesis of gobichelin B: A mixed-ligand siderophore of: Streptomyces sp. NRRL F-4415
Sridhar, Perali Ramu,Venkatesh,Kalesha, Shaik,Sudharani, Chalapala
, p. 3732 - 3740 (2018/05/30)
The first total synthesis of a structurally diverse mixed ligand siderophore, gobichelin B produced by Streptomyces sp. NRRL F-4415, is reported. The systematic assembly of the building blocks to synthesize Gob-B 1st half and Gob-B 2nd half and subsequent coupling of these two fragments followed by global deprotection using Pearlman's catalyst led to the isolation of gobichelin B in excellent yield and purity.
ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF
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Page/Page column 229, (2010/02/10)
Compounds that are VLA-1 integrin antagonists are disclosed. Also disclosed are compositions containing such compounds, and methods of using such compounds in treating diseases mediated, at least in part, by the VLA-1 integrin.
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors
Dales, Natalie A.,Gould, Alexandra E.,Brown, James A.,Calderwood, Emily F.,Guan, Bing,Minor, Charles A.,Gavin, James M.,Hales, Paul,Kaushik, Virendar K.,Stewart, Michael,Tummino, Peter J.,Vickers, Chad S.,Ocain, Timothy D.,Patane, Michael A.
, p. 11852 - 11853 (2007/10/03)
Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and se
Synthesis and Structure-Activity Relationships of a Novel Series of Non-Peptide Angiotensin II Receptor Binding Inhibitors Specific for the AT2 Subtype
Blankley, C. John,Hodges, John C.,Klutchko, Sylvester R.,Himmelsbach, Richard J.,Chucholowski, Alexander,et al.
, p. 3248 - 3260 (2007/10/02)
Structure-activity relationships are reported for a novel class of 4,5,6,7-tetrahydro-1H-imidazopyridine-6-carboxylic acid derivatives that displace 125I-labeled angiotensin II from a specific subset of angiotensin II (Ang II) binding sites in rat
Phenacyl-Directed Alkylation of Imidazoles: A New Regiospecific Synthesis of 3-Substituted L-Histidines
Chivikas, Cleo J.,Hodges, John C.
, p. 3591 - 3594 (2007/10/02)
A new strategy for regiospecific imidazole alkylation of suitably protected histidines is described wherein a phenacyl group serves as a protecting group of the distal imidazole nitrogen atom.Alkylation of N-BOC-1-phenacyl-L-histidine methyl ester at N(3)
Regiospecific Synthesis of 3-Substituted L-Histidines
Hodges, John C.
, p. 20 - 24 (2007/10/02)
3-Substituted L-histidine derivatives were prepared by a regiospecific alkylation of N,1-bis-Boc-L-histidine methyl ester with in situ-generated alkyl triflates, benzyl triflates, and benzyl mesylates.Subsequent acid hydrolysis of N-Boc and methyl ester p
