109230-70-8

Basic information

• Product Name: 4-nitro-1-(2,2,3,3,3-pentafluoropropoxy)benzene
• Synonyms: 4-nitro-1-(2,2,3,3,3-pentafluoropropoxy)benzene
• CAS NO: 109230-70-8
• Molecular Weight: 271.144
• Mol File: 109230-70-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-nitro-1-(2,2,3,3,3-pentafluoropropoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitro-1-(2,2,3,3,3-pentafluoropropoxy)benzene(109230-70-8)
• EPA Substance Registry System: 4-nitro-1-(2,2,3,3,3-pentafluoropropoxy)benzene(109230-70-8)

Safety Data

• Hazardous Substances Data: 109230-70-8(Hazardous Substances Data)

Upstream product

• 422-05-9 2,2,3,3,3-pentafluoropropyl alcohol 
• 350-46-9 4-Fluoronitrobenzene 
• 636-98-6 p-nitrobenzene iodide 
• 100-02-7 4-nitro-phenol 
• 813-31-0 <1H,1H-Pentafluor-propyl>-methansulfonat 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 175691-04-0 4-(2,2,3,3,3-pentafluoropropoxy)phenylhydrazine 
• 1027921-31-8 [4-(2,2,3,3,3-Pentafluoro-propoxy)-phenyl]-carbamic acid phenyl ester 
• 1026053-63-3 C₁₀H₁₀F₅N₃O₂ 
• 131395-22-7 4-(2,2,3,3,3-pentafluoropropoxy)phenylamine 

Relevant articles and documents

BrettPhos ligand supported palladium-catalyzed C-O bond formation through an electronic pathway of reductive elimination: Fluoroalkoxylation of activated aryl halides

We report an unprecedented BrettPhos ligand supported Pd-catalyzed C-O bond-forming reaction of activated aryl halides with primary fluoroalkyl alcohols. We demonstrate that the Phosphine ligand (BrettPhos) possesses the property of altering the mechanistic pathway of reductive elimination from nucleophile to nucleophile. The Pd/BrettPhos catalyst system facilitates the reductive elimination of the oxygen nucleophile through an electronic pathway.

INHIBITORS OF LEUKOTRIENE A4 HYDROLASE

The present invention is directed to compounds encompassed by the Formula (I), pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and methods for the treatment of a disease and disorder which is ameliorated by the inhibition of LTA4h activity. Non-limiting examples of such diseases and conditions include inflammatory and autoimmune diseases and disorders.

Various synthetic approaches to fluoroalkyl p-nitrophenyl ethers

Homologous 1H,1H-perfluoroalkyl p-nitrophenyl ethers (alkyl = C2-C8) were synthesized using different methods. The results are discussed in context with contradictory comments of the literature. The fluoroalkoxylation of p-chloronitrobenzene occurs in only one step, but it is limited to small fluoroalkyl groups. The fluoroalkylation of p-nitrophenol via sulphonic acid esters is a better synthetic route. Differences in reactivity and yield between tosylates, mesylates and inflates are found and discussed. The preferred synthesis includes the use of trifluoromethane sulphonic acid esters.