109256-01-1Relevant academic research and scientific papers
Synthesis of a new class of spirooxindole-benzo[b]thiophene-based molecules as acetylcholinesterase inhibitors
Al-Majid, Abdullah Mohammed,Alamary, Abdullah Saleh,Ali, M.,Alshahrani, Saeed,Altowyan, Mezna Saleh,Ashraf, Sajda,Barakat, Assem,Islam, Mohammad Shahidul,Ul-Haq, Zaheer
, (2020)
A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated. All the synthesized compounds exhibite
Pd-catalyzed C-H olefination of (hetero)arenes by using saturated ketones as an olefin source
Shang, Yaping,Jie, Xiaoming,Zhou, Jun,Hu, Peng,Huang, Shijun,Su, Weiping
supporting information, p. 1299 - 1303 (2013/03/13)
Tolerant: By using Pd(OAc)2/PCy3 as a catalyst, both electron-rich aromatic heterocycles and electron-deficient fluorobenzenes undergo the dehydrogenative cross-coupling with (hetero)aryl ethyl ketones in good yields. A broad range of functional groups is tolerated, thus providing a general method for the facile syntheses of chalcones or heterocyclic chalcone analogues. Furthermore, dialkyl ketones can also participate in this transformation. Copyright
