109271-92-3

Upstream product

• 1868-88-8 2-(3-chloro-4-fluorophenyl)-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 
• 100-63-0 phenylhydrazine 
• 2923-66-2 3-chloro-4-fluoroacetophenone 

Downstream Products

• 131520-59-7 5-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-ylmethylene]-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 109272-19-7 2-{[1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-pentafluorophenyl-meth-(E)-ylidene]-thiazolidin-4-one 
• 109272-17-5 2-{[1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 
• 109272-20-0 5-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-2-{[1-[2-(3-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-thiazolidin-4-one 
• 109272-18-6 2-{[1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 

Relevant academic research and scientific papers

Green approach for the synthesis of 3-methyl-1-phenyl-4-((2-phenyl-1H-indol 3-yl)methylene)-1H-pyrazole-5(4H)-ones and their DNA Cleavage, antioxidant, and antimicrobial activities

3-Methyl-1-phenyl-4-((2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-ones (5a-i) was prepared by the condensation reaction of different 3-formyl-2-phenylindole derivatives (2a-i) and 3-methyl-1-phenyl-2-pyrazoline-5-one in quantitative yield by applying various green synthetic methods as grinding, microwave irradiation using different catalysts under solvent-free mild reaction conditions with high product yields. The structures of the synthesized compounds were characterized on the basis of elemental analysis, infrared, 1HNMR, 13C NMR, and mass spectral data. The synthesized compounds were screened for free radical scavenging, antimicrobial, and DNA cleavage activities. Most of the tested compounds belonging to the 3-methyl-1-phenyl-4-((2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-ones series exhibited promising activities.

Synthesis, spectral, and antimicrobial studies of 1-butyl-3-substituted-4-(2-aryl-1H-indol-3-yl)-2-azetidinones

Ketene generated from acetyl chloride or chloroacetyl chloride adds on indolyl Schiff's base double bond to afford 1-butyl-3-substituted-4-(2-aryl-1H-indol-3-yl)-2-azetidinones in THF. The reaction proceeds stereospecifically via concerted trans cycloaddi