330-58-5

Basic information

• Product Name: 3-(Trifluoromethyl)Diphenyl Ether
• Synonyms: 3-(Trifluoromethyl)Diphenyl Ether;3-(Trifluoromethyl)phenoxybenzene;m-(Trifluoromethyl)diphenyl ether;1-Phenoxy-3-(trifluoroMethyl)benzene
• CAS NO: 330-58-5
• Molecular Formula: C₁₃H₉F₃O
• Molecular Weight: 238.2051696
• Product Categories: Fluorine series
• Mol File: 330-58-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 260℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.230
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(Trifluoromethyl)Diphenyl Ether(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Trifluoromethyl)Diphenyl Ether(330-58-5)
• EPA Substance Registry System: 3-(Trifluoromethyl)Diphenyl Ether(330-58-5)

Safety Data

• Hazardous Substances Data: 330-58-5(Hazardous Substances Data)

Usage

General Description

3-(Trifluoromethyl)Diphenyl Ether, also known as trifluoromethyl diphenyl ether or triphenyl ether with a trifluoromethyl group, is a chemical compound with the formula C18H11F3O. It is a colorless solid with a molecular weight of 296.3 g/mol. 3-(Trifluoromethyl)Diphenyl Ether is commonly used in organic synthesis and as a solvent. Its unique properties make it useful in a variety of applications, including in the production of plastics, pharmaceuticals, and other industrial processes. However, it is important to handle this compound with caution due to its potential health and environmental hazards.

Upstream product

• 98-15-7 3-chlorotrifluoromethylbenzene 
• 108-95-2 phenol 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 1440730-05-1 2-(3-trifluoromethylphenoxy)phenyl pivalate 
• 98-17-9 3-Trifluoromethylphenol 
• 66003-76-7 Diphenyliodonium triflate 
• 591-50-4 iodobenzene 
• 109272-26-6 1-Phenoxy-3-(tris-ethylsulfanyl-methyl)-benzene 
• 3586-15-0 3-phenoxy-benzoyl chloride 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 109272-29-9 meta-(4-bromophenoxy)-benzotrifluoride 
• 139-02-6 sodium phenoxide 
• 81447-72-5 m-(trifluoromethyl)diphenyliodonium iodide 

Downstream Products

• 98-17-9 3-Trifluoromethylphenol 

Relevant articles and documents

A green approach for arylation of phenols using iron catalysis in water under aerobic conditions

The first efficient iron-catalyzed coupling of aryl iodides with phenols was developed exclusively with water as solvent. The reaction is performed with low cost and readily available FeCl3·6H2O and DMEDA catalytic system providing diaryl ethers in good to excellent yields. The effectiveness of this reaction was further revealed by compatibility with a wide range of functional groups. Moreover, the procedure is rendered simple as this transformation is carried out in the presence of air. Thus, the protocol represents a facile, economical and eco-friendly procedure to access diaryl ethers.

A counteranion triggered arylation strategy using diaryliodonium fluorides

A mild and transition metal-free counteranion triggered arylation strategy has been developed using diaryliodonium fluorides. The fluoride counteranion within the hypervalent iodonium species displays unusual reactivity that activates a phenolic O-H bond leading to electrophilic O-arylation. A wide range of phenols and diaryliodonium salts are compatible with this transformation under remarkably mild conditions. Furthermore, we pre-empt the wider implications of this strategy by demonstrating the compatibility of the arylation tactic with latent carbon nucleophiles.

Nickel-catalyzed intramolecular C-H arylation using aryl pivalates as electrophiles

This paper describes a method for nickel catalyzed intramolecular C-H arylation using aryl pivalates as electrophiles. The transformation is efficient for the synthesis of diverse electronically and sterically differentiated dibenzofurans. Additionally, the method could be expanded toward the synthesis of carbazoles. Preliminary mechanistic studies of the transformation are also described.