109319-83-7

Upstream product

• 101252-73-7 2-Chlor-6-nitrobenzylamin 
• 6575-11-7 2-amino-6-chlorobenzonitrile 
• 109319-74-6 N-(2-Chlor-6-nitrobenzyl)phthalimid 
• 56433-01-3 2-chloro-6-nitrobenzyl bromide 
• 83-42-1 6-chloro-2-nitrotoluene 

Downstream Products

• 1431959-29-3 N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride 
• 1431960-59-6 C₁₀H₁₁ClN₂O 
• 1431960-58-5 C₁₅H₁₉ClN₂O₃ 
• 1431960-57-4 tert-butyl 2-amino-6-chlorobenzylcarbamate 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The invention is directed to substituted heteroaryl derivatives. Specifically, the invention is directed to compounds according to Formula Q: wherein D, L, M, W, X, Y, and Z are defined herein. The compounds of the invention are inhibitors of DNA methyltransferase (DNMT) activity - including DNMT1, DNMT3a, or DNMT3b- and are useful in the treatment of cancer and hyperproliferative diseases. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention

Pyrrolidine(thi)ones Substituted by Heterocyclic Substituents in The 3-Position

Pyrrolidine(thi)one compounds substituted by heterocyclic substituents in the 3-position, their preparation and use in pharmaceutical compositions, in particular as immunomodulators for treatment and/or inhibition of inflammatory and autoimmune diseases and haematological-oncological diseases.