1094473-56-9

Upstream product

• 603-76-9 1-methylindole 
• 201230-82-2 carbon monoxide 
• 5467-74-3 4-Bromophenylboronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 120-72-9 indole 
• 673-40-5 4-bromobenzenediazonium tetrafluoroborate 
• 99-90-1 para-bromoacetophenone 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 1620742-32-6 C₁₆H₁₄BrN 

Relevant academic research and scientific papers

Electrochemically Enabled C3-Formylation and -Acylation of Indoles with Aldehydes

Reported herein is an effective strategy for oxidative cross-coupling of indoles with various aldehydes. The strategy is based on a two-step transformation via a well-known Mannich-type reaction and a C-N bond cleavage for carbonyl introduction. The key step - the C-N bond cleavage of the Mannich product - was enabled by electrochemistry. This strategy (with over 40 examples) ensures excellent functional-group tolerance as well as late-stage functionalization of pharmaceutical molecules.

Synthesis of indol-3-yl aryl ketones through visible-light-mediated carbonylation

A visible-light-catalyzed synthesis of indol-3-yl aryl ketones from aryldiazonium salts, CO and indoles at room temperature was developed. This process provides a useful method for the preparation of diverse indol-3-yl aryl ketones from readily accessible reactants under base-free, acid-free and transition-metal-free conditions.

Acylation of indoles via photoredox catalysis: A route to 3-acylindoles

A visible-light-induced synthesis of 3-acylindoles from simple indoles and α-oxo acids at room temperature has been discovered. The reaction tolerates a wide range of functional groups and gives a variety of valuable 3-acylindoles in moderate to high yields under mild conditions.

Palladium-catalyzed carbonylation of indoles for synthesis of indol-3-yl aryl ketones

A novel palladium-catalyzed carbonylation of indoles with CO and aromatic boronic acids for the synthesis of indol-3-yl aryl ketones was developed. The reaction tolerates a wide range of functional groups and gives a variety of valuable indol-3-yl aryl ketones in high yields under mild conditions. (Chemical Presented).

A metal free domino synthesis of 3-aroylindoles via two sp3 C-H activation

A metal free synthesis of 3-aroylindole involving two sp3 C-H activation has been achieved starting from o-alkynyl-N,N-dialkylamines using catalyst TBAI and oxidant TBHP. This journal is the Partner Organisations 2014.

Copper-promoted decarboxylative direct C3-acylation of N-substituted indoles with α-oxocarboxylic acids

A novel and efficient Cu-promoted decarboxylative direct C3-acylation of N-substituted indoles with α-oxocarboxylic acids for the synthesis of 3-acylindoles was developed. The Royal Society of Chemistry.