109496-98-2

Basic information

• Product Name: 5-Phenylisatin
• Synonyms: 5-Phenylisatin
• CAS NO: 109496-98-2
• Molecular Formula: C₁₄H₉NO₂
• Molecular Weight: 223.22676
• Mol File: 109496-98-2.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Phenylisatin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Phenylisatin(109496-98-2)
• EPA Substance Registry System: 5-Phenylisatin(109496-98-2)

Safety Data

• Hazardous Substances Data: 109496-98-2(Hazardous Substances Data)

Usage

General Description

5-Phenylisatin is a chemical compound that belongs to the class of isatin derivatives, which are often used in organic synthesis and medicinal chemistry. It is a yellow crystalline powder with a molecular formula of C14H9NO2 and a molecular weight of 223.23 g/mol. 5-Phenylisatin has been studied for its potential pharmacological activities, including its ability to inhibit the growth of cancer cells and its anti-inflammatory effects. It has also been investigated for its potential use as a fluorescent probe for detecting trace amounts of copper ions in biological samples. Additionally, 5-Phenylisatin has been used in the synthesis of various bioactive compounds and as a reagent in organic chemistry reactions. Overall, 5-Phenylisatin holds promise for various applications in medicinal and chemical research due to its diverse range of potential properties and uses.

Upstream product

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Downstream Products

• 1412900-45-8 7-allyl-2-phenyl-7,8-dihydrodibenzo[e,g][1,4]diazocin-6(5H)-one 
• 1412900-38-9 3-allyl-3-((2-bromophenyl)amino)-5-phenylindolin-2-one 

Relevant articles and documents

Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13

Matrix metalloproteinases (MMPs) are well-established targets for several pathologies. In particular, MMP-2 and MMP-13 play a prominent role in cancer progression. In this study, a structure-based screening campaign was applied to prioritize metalloproteinase-oriented fragments. This computational model was applied to a representative fragment set from the publically available EDASA Scientific compound library. These fragments were prioritized, and the top-ranking hits were tested in a biological assay to validate the model. Two scaffolds showed consistent activity in the assay, and the isatin-based compounds were the most interesting. These latter fragments have significant potential as tools for the design and realization of novel MMP inhibitors. In addition to their micromolar activity, the chemical synthesis affords flexible and creative access to their analogues.

Polyphenylglyoxamide‐based amphiphilic small molecular peptidomimetics as antibacterial agents with anti‐biofilm activity

The rapid emergence of drug‐resistant bacteria is a major global health concern. Antimicrobial peptides (AMPs) and peptidomimetics have arisen as a new class of antibacterial agents in recent years in an attempt to overcome antibiotic resistance. A librar

NiFe2O4@SiO2@ZrO2/SO42-/Cu/Co nanoparticles: A novel, efficient, magnetically recyclable and bimetallic catalyst for Pd-free Suzuki, Heck and C-N cross-coupling reactions in aqueous media

The novel heterogeneous bimetallic nanoparticles of Cu-Co were synthesized based on magnetic nanoparticles, and the magnetic nanocatalyst was characterized by XRD, FE-SEM, EDX mapping, BET, TEM, HRTEM, FTIR, TGA, and VSM. This catalyst was successfully applied as a recyclable magnetically catalyst in Heck, Suzuki, and C-N cross-coupling reactions with various aryl halides (iodides, bromides, and chlorides as challengeable substrates), with olefins, phenylboronic acid, and amines, respectively. We considered the rise of synergetic effects from the different Lewis acid and Br?nsted acid sites present in the catalyst. The catalyst was synthesized with cheap, available materials and a simple synthesis method. The catalyst can be separated easily using an external magnet. It was recycled for more than ten runs without a sensible loss of its catalytic activity, and no significant leaching of the Cu and Co quantity was observed. The significant benefits of the method are high-level generality, simple operation, and there are no heavy metals and toxic solvents. This is a quick, easy, efficacious and environmentally friendly protocol, and no by-products are formed in the reaction. These features make it an appropriate practical alternative protocol. In comparison with recent works, the other advantage of this catalyst is the synthesis of a wide variety of C-C and C-N bond derivatives (more than 40 derivatives). The other significant advantage is the low temperature of the reaction and the use of the least possible amount of the catalyst (0.003 g). The efficiency was good to excellent and the catalyst selectivity has been high. We aspire that our study inspires more interest to design novel catalysts based on using low-cost metal ions (such as cobalt and copper) in the cross-coupling reactions. This journal is

ANTIMICROBIAL COMPOUNDS

The present application relates to compounds of Formula (I) and salts thereof. The compounds of Formula (I) have antibacterial and anti-biofilm activities. The present application also relates to compositions comprising the compounds of Formula (I) or sal