1095010-47-1

Basic information

• Product Name: 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester
• Synonyms: 1-tert-Butyl 3-methyl 5-hydroxypiperidine-1,3-dicarboxylate;O1-tert-Butyl O3-methyl 5-hydroxypiperidine-1,3-dicarboxylate;Methyl 1-Boc-5-hydroxypiperidine-3-carboxylate
• CAS NO: 1095010-47-1
• Molecular Formula: C₁₂H₂₁NO₅
• Molecular Weight: 259.3
• Mol File: 1095010-47-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 352.1 °C at 760 mmHg
• Flash Point: 166.8 °C
• Appearance: /
• Density: 1.182 g/cm³
• Storage Temp.: 2-8°C
• PKA: 14.33±0.40(Predicted)
• CAS DataBase Reference: 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester(1095010-47-1)
• EPA Substance Registry System: 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester(1095010-47-1)

Safety Data

• Hazardous Substances Data: 1095010-47-1(Hazardous Substances Data)

Usage

Uses

1-tert-Butyl 3-Methyl 5-Hydroxypiperidine-1,3-dicarboxylate is an intermediate used in the synthesis of heterocyclylaminopyrazine derivatives for use as CHK-1 inhibitors. It is also used to prepare pyrrolidinylimidazopyridinylpiperidinylmethanone derivatives and analogs for use as diacylglycerol acyltransferase 2 inhibitors.

Upstream product

• 1095010-48-2 1-(tert-butoxycarbonyl)-5-hydroxypiperidine-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 27828-71-3 5-hydroxynicotinic acid 
• 30766-22-4 methyl 5-hydroxy-3-pyridinecarboxylate 
• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1095010-44-8 methyl 5-hydroxypiperidine-3-carboxylate 

Downstream Products

• 1095010-48-2 1-(tert-butoxycarbonyl)-5-hydroxypiperidine-3-carboxylic acid 
• 1255666-86-4 1-(tert-butoxycarbonyl)-5,5-difluoropiperidine-3-carboxylic acid 
• 1241725-64-3 1-(tert-butoxycarbonyl)-5-fluoropiperidine-3-carboxylic acid 

Relevant articles and documents

INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME

Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor ("MRTF/SRF"), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

SERINE/THREONINE KINASE INHIBITORS

Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.