109522-75-0

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 109522-66-9 *,R^*)>-2-<<<1-Formyl-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 95924-70-2 *,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 2026-48-4 (S)-valinol 

Downstream Products

• 109522-76-1 2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 119720-81-9 (S)-N-Acetyl-L-alanyl-N-<3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-<(2-phenylethyl)amino>butyl>-L-prolinamide 
• 119720-82-0 N-Acetyl-L-alanyl-N-<3,3-difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-L-prolinamide 
• 109522-83-0 N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide 

Relevant academic research and scientific papers

Crystal structure of the covalent complex formed by a peptidyl α,α-difluoro-β-keto amide with porcine pancreatic elastase at 1.78-A resolution

The crystal structure analysis of the covalent enzyme-inhibitor complex of porcine pancreatic elastase (PPE) with a peptidyl α,α-difluoro-β-keto amide has shown that the tightly bound inhibitor forms an hemiketal complex with the O(γ) atom of the catalyti