119720-81-9

Basic information

• Product Name: N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide
• CAS NO: 119720-81-9
• Molecular Formula: C₂₅H₃₄F₂N₄O₅
• Molecular Weight: 508.5581
• Mol File: 119720-81-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 723.7°C at 760 mmHg
• Flash Point: 391.5°C
• Density: 1.223g/cm³
• Vapor Pressure: 8.45E-21mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide(119720-81-9)
• EPA Substance Registry System: N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide(119720-81-9)

Safety Data

• Hazardous Substances Data: 119720-81-9(Hazardous Substances Data)

Upstream product

• 2026-48-4 (S)-valinol 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 95924-70-2 *,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 109522-66-9 *,R^*)>-2-<<<1-Formyl-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 119720-82-0 N-Acetyl-L-alanyl-N-<3,3-difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-L-prolinamide 
• 109522-76-1 2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 109522-75-0 2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 109522-83-0 N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide 

Relevant articles and documents

Crystal structure of the covalent complex formed by a peptidyl α,α-difluoro-β-keto amide with porcine pancreatic elastase at 1.78-A resolution

The crystal structure analysis of the covalent enzyme-inhibitor complex of porcine pancreatic elastase (PPE) with a peptidyl α,α-difluoro-β-keto amide has shown that the tightly bound inhibitor forms an hemiketal complex with the O(γ) atom of the catalyti