109555-51-3

Upstream product

• 109932-47-0 (4-(hydroxy(phenyl)methyl)piperidin-1-yl)(phenyl)methanone 
• 37586-22-4 4-benzoylpiperidine 
• 98-88-4 benzoyl chloride 
• 115755-50-5 1-benzoyl-4-piperidinecarbonyl chloride 
• 71-43-2 benzene 
• 38081-60-6 phenyl-piperidin-4-yl-methanol 
• 31252-42-3 4-benzylpyperidine 
• 120014-29-1 1-benzoyl-piperidine-4-carboxaldehyde 
• 136081-74-8 ethyl 1-benzoyl-4-piperidine-carboxylate 
• 19980-00-8 1-benzoyl-4-hydroxymethyl-piperidine 
• 1126-09-6 4-carbethoxypiperidine 

Downstream Products

• 288316-63-2 [4-(hydroxy-diphenyl-methyl)-piperidin-1-yl]-phenyl-methanone 
• 916976-35-7 (4-benzhydrylidene-piperidin-1-yl)-phenyl-methanone 
• 37586-22-4 4-benzoylpiperidine 

Relevant academic research and scientific papers

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

Synthesis and in vitro and in vivo evaluation of18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter

A new class of vesicular acetylcholine transporter inhibitor that incorporates a carbonyl group into the benzovesamicol structure was synthesized, and analogues were evaluated in vitro. (±)-trans-2-Hydroxy-3- (4-(4-[18F]fluorobenzoyl)piperidino)tetralin (9e) has Ki values of 2.70 nM for VAChT, 191 nM for σ1 and 251 nM for σ2. The racemic precursor (9d) was resolved via chiral HPLC, and (±)-[18F]9e,(-)-[18F]9e, and (+)-[ 18F]9e were respectively radiolabeled via microwave irradiation of the appropriate precursors with [18F]/F- and Kryptofix/K 2CO3 in DMSO with radiochemical yields of ～50-60% and specific activities of >2000 mCi/μmol. (-)-[18F]9e uptake in rat brain was consistent with in vivo selectivity for the VAChT with an initial uptake of 0.911 %ID/g in rat striatum and a striatum/cerebellum ratio of 1.88 at 30 min postinjection (p.i.). MicroPET imaging of macaques demonstrated a 2.1 ratio of (-)-[18F]9e in putamen versus cerebellum at 2 h p.i. (-)-[18F]9e has potential to be a PET tracer for clinical imaging of the VAChT.

Synthesis of diarylazepan-4-ones

Synthesis of several 3,3-diarylazepan-4-ones and 5,5-diarylazepan-4-ones has been established starting from two tetrasubstituted olefins, which is derived from commercially available piperidine-3-carboxylic acid ethyl ester and piperidine-4-carboxylic aci

CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.