19980-00-8

Upstream product

• 136081-74-8 ethyl 1-benzoyl-4-piperidine-carboxylate 
• 2971-79-1 isonipecotic acid methyl ester 
• 5274-99-7 1-benzoylisonipecotic acid 
• 543-27-1 isobutyl chloroformate 
• 98-88-4 benzoyl chloride 
• 6457-49-4 4-piperidinemethanol 
• 17037-68-2 (4-methylpiperidin-1-yl)(phenyl)methanone 
• 613-90-1 benzoyl cyanide 
• 1126-09-6 4-carbethoxypiperidine 

Downstream Products

• 184921-12-8 1-benzoyl-piperidin-4-ylmethyl methanesulfonate 
• 120013-38-9 2-((1-benzoylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 
• 67686-01-5 1-benzyl-4-piperidinemethanol 
• 120014-29-1 1-benzoyl-piperidine-4-carboxaldehyde 
• 63608-15-1 (4-(chloromethyl)piperidin-1-yl)(phenyl)methanone 
• 313502-54-4 (+)-trans-1-hydroxymethyl-4-oxo-2-phenylcyclopentane 
• 351532-13-3 2-[1-(3-iodo-benzyl)-piperidin-4-ylmethyl]-5,6-dimethoxy-indan-1-one 
• 149874-90-8 1-benzoyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine 
• 109932-47-0 (4-(hydroxy(phenyl)methyl)piperidin-1-yl)(phenyl)methanone 
• 109555-51-3 1-benzoyl-4-benzoylpiperidine 
• 916976-35-7 (4-benzhydrylidene-piperidin-1-yl)-phenyl-methanone 

Relevant academic research and scientific papers

A Bond-Weakening Borinate Catalyst that Improves the Scope of the Photoredox α-C-H Alkylation of Alcohols

The development of catalyst-controlled, site-selective C(sp 3)-H functionalization reactions is currently a major challenge in organic synthesis. In this paper, a novel bond-weakening catalyst that recognizes the hydroxy group of alcohols through formation of a borate is described. An electron-deficient borinic acid-ethanolamine complex enhances the chemical yield of the α-C-H alkylation of alcohols when used in conjunction with a photoredox catalyst and a hydrogen atom transfer catalyst under irradiation with visible light. This ternary hybrid catalyst system can, for example, be applied to functional-group-enriched-peptides.

Straightforward α-Amino Nitrile Synthesis Through Mo(CO)6-Catalyzed Reductive Functionalization of Carboxamides

The selective reduction of amides into an intermediate hemiaminal catalyzed by Mo(CO)6 together with the inexpensive and easy to handle TMDS (1,1,3,3-tetramethyldisiloxane) as reducing agent, followed by subsequent trapping of the hemiaminal with a cyanide source, allows for the straightforward synthesis of α-amino nitriles. The methodology presented here, displays high levels of chemoselectivity allowing for the reduction of amides in the presence of functional groups such as ketones, imines, aldehydes, and acids, which affords a simple route for the synthesis of α-amino nitriles with a broad scope of functionalities in high yields. Furthermore, the applicability of this methodology is demonstrated by scale up experiments and by derivatization of the target compounds into synthetically interesting products. The selective cyanation is successfully applied in late stage functionalizations of amide containing drugs and prolinol derivatives.

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Compounds IV

The present application relates to new compounds of formula (I), to pharmaceutical compositions comprising the compounds, to processes for their preparation, and to the use of the compounds as leptin receptor modulator mimetics in the preparation of medic

Highly chemoselective metal-free reduction of tertiary amides

This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance. Copyright

Synthesis of diarylazepan-4-ones

Synthesis of several 3,3-diarylazepan-4-ones and 5,5-diarylazepan-4-ones has been established starting from two tetrasubstituted olefins, which is derived from commercially available piperidine-3-carboxylic acid ethyl ester and piperidine-4-carboxylic aci

2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation

The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula I The present invention also provides methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangl

SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE

The present invention is directed to certain silanol derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for p

Pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R14and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.

Biohydroxylation reactions catalyzed by enzymes and whole-cell systems

The biohydroxylation of a number of cyclic substrates (3-24) containing aromatic side chains was used to compare substrate specificity and selectivity of hydroxylation using microbial enzymes and whole-cell biocatalysts. In general, the regioselectivity of reaction was remarkably similar between the different catalysts in that little aromatic or benzylic, but significant aliphatic hydroxylation was observed. However, a more detailed investigation of isolated products showed complementary substrate specificity, functional group compatibility, and regioselectivity of hydroxylation. Substrate specificity and regioselectivity could be further modulated by small changes to the nature of the aromatic side chain, which appears to play an important role in substrate recognition.