109932-47-0

Upstream product

• 38081-60-6 phenyl-piperidin-4-yl-methanol 
• 98-88-4 benzoyl chloride 
• 120014-29-1 1-benzoyl-piperidine-4-carboxaldehyde 
• 1126-09-6 4-carbethoxypiperidine 
• 19980-00-8 1-benzoyl-4-hydroxymethyl-piperidine 
• 37586-22-4 4-benzoylpiperidine 
• 136081-74-8 ethyl 1-benzoyl-4-piperidine-carboxylate 

Downstream Products

• 916976-35-7 (4-benzhydrylidene-piperidin-1-yl)-phenyl-methanone 
• 109555-51-3 1-benzoyl-4-benzoylpiperidine 

Relevant academic research and scientific papers

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

Synthesis of diarylazepan-4-ones

Synthesis of several 3,3-diarylazepan-4-ones and 5,5-diarylazepan-4-ones has been established starting from two tetrasubstituted olefins, which is derived from commercially available piperidine-3-carboxylic acid ethyl ester and piperidine-4-carboxylic aci