1096689-22-3Relevant academic research and scientific papers
Method for synthesizing impurities in contrast agent intermediate preparation
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Paragraph 0030; 0037-0038; 0053-0054, (2018/09/08)
The invention discloses a method for synthesizing impurities shown in the formula (I) when preparing a contrast agent intermediate. The method comprises that (1) a compound (II) and R2NH2 undergo a reaction to produce a compound (III), wherein R1 represents a lower alkane group having 1 to 4 carbon atoms and R2 represents any one of -CH2CH(OH)CH2(OH) and -CH(CH2OH)2, (2) the compound (III) is reacted with R3NH2 under basic conditions to produce a compound (IV), wherein when R2 represents -CH2CH(OH)CH2(OH), R3 represents -CH(CH2OH)2, and when R2 represents -CH(CH2OH)2, R3 represents -CH2CH (OH)CH2(OH), (3) the compound (IV) undergoes a nitro reduction reaction to produce a compound (V), and (4) the compound (V) is processed into a compound (I) through an iodination reagent.
CONTRAST AGENTS
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, (2011/04/14)
The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CO—CH3)XN(CO—CH3)—R and salts or optical active isomers thereof, wherein X denotes a divalent linking moiety with 5 to 10 bridge elements of carbon, oxygen, sulphur and nitrogen separating the acetylated nitrogen atoms, and which may be further substituted by hydroxyl groups, by C1 to C4 alkyl moieties optionally substituted by hydroxyl groups, by C1 to C4 alkoxy groups, by amino groups and by C1 to C4 alkylamino groups, and wherein 2 or 3 carbon bridge elements together with alkyl or alkoxy groups form a cyclopentane, cyclohexane, pentahydropyran or tetrahydrofuran entity which may be alkyl- or hydroxyalkyl-substituted and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
CONTRAST AGENTS
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Page/Page column 32-33, (2009/10/21)
The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R-N(CO-CH3)-X-N(CO-CH3)-R and salts or optical active isomers thereof, wherein X denotes a C3 to C4 straight or branched alkylene moiety wherein the alkylene moiety is substituted by one or two hydroxyl groups, optionally hydroxylated alkyl groups and/or alkoxy groups; and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
