109722-47-6Relevant academic research and scientific papers
Diverse synthesis of pyrimido[1,2-a]benzimidazoles and imidazo[2,1-b]benzothiazoles via CuI-catalyzed decarboxylic multicomponent reactions of heterocyclic azoles, aldehydes and alkynecarboxylic acids
Wu, Jiarong,Luo, Huan,Wang, Tao,Sun, Huaming,Zhang, Qi,Chai, Yonghai
, p. 1052 - 1063 (2019/01/25)
We have developed a straightforward approach to diverse synthesis of 2,3-, 2,4-disubstituted pyrimido [1,2-a]benzimidazoles, 2,4,10-trisubstituted 2,10-dihydropyrimido [1,2-a]benzimidazoles and 2,3-disubstituted imidazo [2,1-b]benzothiazoles via multicomp
Iron Catalysis for Modular Pyrimidine Synthesis through β-Ammoniation/Cyclization of Saturated Carbonyl Compounds with Amidines
Chu, Xue-Qiang,Cao, Wen-Bin,Xu, Xiao-Ping,Ji, Shun-Jun
, p. 1145 - 1154 (2018/06/18)
An efficient method for the modular synthesis of various pyrimidine derivatives by means of the reactions of ketones, aldehydes, or esters with amidines in the presence of an in situ prepared recyclable iron(II)-complex was developed. This operationally simple reaction proceeded with broad functional group tolerance in a regioselective manner via a remarkable unactivated β-C-H bond functionalization. Control experiments were performed to gain deep understanding of the mechanism, and the reactions are likely to proceed through a designed TEMPO complexation/enamine addition/transient α-occupation/β-TEMPO elimination/cyclization sequence.
A Simple Regioselective Synthesis of Pyrimidobenzimidazoles
Tseng, Shin-Shyong,Epstein, Joseph W.,Brabander, Herbert J.,Francisco, Gerardo
, p. 837 - 843 (2007/10/02)
2-Aminobenzimidazoles were reacted with enaminones in acetic acid to give pyrimidobenzimidazoles.With a substituted enaminone only one regioisomer was obtained.Structural assignments based on nmr and uv spectroscopy are presented.Possible pathways
