1098070-07-5Relevant academic research and scientific papers
Palladium-Catalyzed Decarboxylative Ortho-Ethoxycarbonylation of O-Methyl Ketoximes and 2-Arylpyridines with Potassium Oxalate Monoester
Li, Zhong-Yuan,Wang, Guan-Wu
, p. 4866 - 4869 (2015)
A novel method for introducing an ester group via palladium-catalyzed ligand-directed C-H activation has been explored. The ortho-ethoxycarbonylation of O-methyl ketoximes proceeded smoothly with the nontoxic and easily handled reagent potassium oxalate monoester, affording the desired products in moderate to good yields. Furthermore, pyridine could also be employed as a directing group to obtain similar results in this transformation.
Palladium-catalyzed oxime ether directed regioselective C-H alkoxylation of arenes
Pan, Liang,Wang, Liang,Chen, Qun,He, Mingyang
supporting information, p. 1981 - 1988 (2016/12/09)
A palladium-catalyzed highly regioselective ortho-C(sp2)-H alkoxylation of oxime ethers with PhI(OAc)2as the oxidant and alcohols as the alkoxylation reagents has been developed. Mono-alkoxylated and acetoxylated products could be selectively obtained via tuning the reaction conditions. A series of oxime ethers were tolerated, affording the corresponding products in moderate to good yields. Both primary and secondary alcohols survived the reaction conditions. Moreover, the directing group can be easily removed, thereby providing a straightforward access to substituted aryl ketones.
