109809-45-2

Upstream product

• 4979-79-7 4-chloro-2-phenylquinoline 
• 124-40-3 dimethyl amine 
• 127-19-5 N,N-dimethyl acetamide 
• 758-96-3 N,N-dimethyl-propanamide 
• 68-12-2 N,N-dimethyl-formamide 
• 180689-33-2 3-(2-aminophenyl)-1-phenyl-2-propyn-1-one 
• 197729-98-9 α-[2-(2-aminophenyl)ethynyl]benzenemethanol 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 615-43-0 2-iodophenylamine 

Relevant academic research and scientific papers

An Improved Environmentally Friendly Approach to 4-Nitro-, 4-Sulfonyl-, and 4-Aminoquinolines and 4-Quinolones through Conjugate Addition of Nucleophiles to β-(2-Aminophenyl)-α,β-ynones

Sequential addition/annulation reactions of sulfinate and nitrite anions to β-(2-aminophenyl)-α,β-ynones led to valuable 4-sulfonylquinolines and 4-nitroquinolines. The latter proved to be versatile precursors of N-unsubstituted 4-aminoquinolines and 4-quinolones. Reaction of β-(2-aminophenyl)-α,β-ynones with DMF/NaOH resulted in the formation of 4-(dimethylamino)quinolines. The use of an alternative CO-free procedure for the preparation of substrates β-(2-aminophenyl)-α,β-ynones allowed extension of the methodology to the synthesis of 4-substituted 2-alkylquinolines.

Investigation of amination in 4-chloro-2-phenylquinoline derivatives with amide solvents

Novel 4-amino-2-phenylquinoline derivatives were synthesized by reacting various 4-chloro-2-arylquinoline compounds having activated chloro group with the corresponding amide solvents at reflux for overnight. The activity of amination by the amide solvent