109809-47-4

Upstream product

• 29681-94-5 3-phenyl-1,4,5,6-tetrahydropyridazine 
• 98-88-4 benzoyl chloride 
• 1011-46-7 6-phenyl-2,3,4,5-tetrahydropyridazin-3-one 
• 2051-95-8 succinylbenzene 
• 74-85-1 ethene 
• 857769-21-2 α-chloro-N-benzoylhydrazone 

Relevant academic research and scientific papers

Cycloaddition of in situ generated 1,2-diaza-1,3-dienes with simple olefins: Facile approaches to tetrahydropyridazines

A catalyst-free [4 + 2] annulation process between in situ generated 1,2-diaza-1,3-butadienes and simple olefins has been developed. Under mild conditions, the reactions afforded 1,4,5,6-tetrahydropyridazines, which feature a wide range of bioactive compounds, with high yields (up to 99% yield).

Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors

A novel series of nonsteroidal heterocycles was discovered which display cell-type selective, high-affinity (nanomolar) binding to the progesterone receptors from TE85 osteosarcoma cells but > 1 μM binding affinity to the progesterone receptors from T47D and ZR75 human breast carcinpma cells.Structure-activity relationships were developed for a set of these compounds, and a representative analog 1-(3,4-dichlorobenzoyl)-3-phenyl-1,4,5,6-tetrahydropyridazine (1i, RWJ 25333) was chosen for further evaluation.RWJ 25333 stimulated the in vitro proliferation of human osteoblast-like cells but not human breast cells.