109872-93-7Relevant academic research and scientific papers
Platinum(II) photo-catalysis for highly selective difluoroalkylation reactions
Zhong, Jian-Ji,Yang, Chen,Chang, Xiao-Yong,Zou, Chao,Lu, Wei,Che, Chi-Ming
, p. 8948 - 8951 (2017)
The platinum(ii) photo-catalyzed difluoroalkylation of cinnamic acids and alkynes for selective construction of E-,Z-difluoroalkyl alkenes and difluoroalkyl alkenyl iodides, respectively, were achieved under mild conditions. The high efficiency, good substrate scope and high selectivity altogether highlight the prospect of Pt(ii) photocatalysts in visible-light-driven organic transformation reactions.
N-heterocyclic carbene (NHC) catalyzed synthesis of α,α- difluoro esters
Dong, Xiuqin,Zhao, Yu-Ming,Sun, Jianwei
supporting information, p. 1221 - 1224 (2013/07/11)
A process for the synthesis of α,α-difluoro esters by NHC-catalyzed fluorination is described. The internal redox process exhibits good efficiency, selectivity, and functional-group compatibility. It provides an alternative strategy for the formation of the useful gem-difluoromethylene unit in organic molecules. Georg Thieme Verlag Stuttgart. New York.
Enantioselective synthesis of β,γ-unsaturated α-fluoroesters catalyzed by N-heterocyclic carbenes
Zhao, Yu-Ming,Cheung, Man Sing,Lin, Zhenyang,Sun, Jianwei
, p. 10359 - 10363 (2012/11/14)
NHC meets F: NHC-bound enolates undergo a catalytic asymmetric fluorination reaction to β,γ-unsaturated α-fluoroesters, which are obtained with good efficiency and stereoselectivity (see scheme, NFSI=N- fluorobenzenesulfonimide). The strategy overcomes possible challenges, such as fluorination in the γ position and difluorination. Experimental evidence combined with DFT calculations provides insight into the reaction mechanism. Copyright
SYNTHESIS OF 2,2-DIFLUOROESTERS BY IODODIFLUOROACETATE-COPPER WITH ORGANIC HALIDES
Taguchi, Takeo,Kitagawa, Osamu,Morikawa, Tsutomu,Nishiwaki, Tohru,Uehara, Hideya,et al.
, p. 6103 - 6106 (2007/10/02)
C-C bond formation through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield.With alkenyl iodides, these reactions are stereospecific.
