109923-56-0

Upstream product

• 109923-55-9 N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-2'-O-tosyladenosine 
• 58-61-7 adenosine 
• 118364-68-4 3',5'-bis-O-(t-butyldimethylsilyl)-N⁶-(4,4'-dimethoxytrityl)adenosine 
• 98-59-9 p-toluenesulfonyl chloride 
• 69504-03-6 3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-adenosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Relevant academic research and scientific papers

The Synthesis of C-Methyl Branched-Chain Deoxy Sugar Nucleosides by the Deoxygenative Methylation of O-Tosylated Adenosines with Grignard Reagents

The reaction of appropiately protected 2'-O-tosyladenosines with methylmagnesium bromide (or iodide) gave 9-(2-deoxy-3-C-methyl-β-D-threopentofuranosyl)adenine after deprotection.The same reaction on 3'-O-tosyladenosine derivatives afforded an epimeric pair of 2'-C-methyl-3'-deoxy sugar nucleosides.The modified structures of the sugar moieties were determined unambiguously.