109936-21-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-CHLOROPHENYL)-1,1-DIPHENYLETHANOL is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows it to be a versatile building block for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry Research:
2-(4-CHLOROPHENYL)-1,1-DIPHENYLETHANOL is used as a research compound for studying its potential anti-inflammatory and analgesic properties. Its biological activity and potential therapeutic applications are being investigated to explore its use in the development of new medications.
Used in Organic Synthesis:
2-(4-CHLOROPHENYL)-1,1-DIPHENYLETHANOL is used as a starting material or intermediate in various organic synthesis processes. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules and compounds.

InChI:InChI=1/C20H17ClO/c21-19-13-11-16(12-14-19)15-20(22,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-14,22H,15H2

Upstream product

• 119-61-9 benzophenone 
• 874-72-6 4-chlorobenzylmagnesium chloride 
• 622-95-7 4-chlorobenzyl bromide 
• 530-48-3 1,1-Diphenylethylene 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 100-58-3 phenylmagnesium bromide 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 1229-73-8 (2-(4-chlorophenyl)ethene-1,1-diyl)dibenzene 
• 108667-89-6 2-bromo-2-(4-chloro-phenyl)-1,1-diphenyl-ethanol 
• 22021-10-9 1-(p-Chlor-phenyl>-2,2-diphenyl-1-iod-aethylen 
• 1394239-97-4 (2R)-2-amino-3-((2-(4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid 
• 796-13-4 1-bromo-1-(4-chloro-phenyl)-2,2-diphenyl-ethene 

Relevant academic research and scientific papers

Visible Light Promoted, Catalyst-Free Radical Carbohydroxylation and Carboetherification under Mild Biomimetic Conditions

Metal and catalyst-free carbohydroxylations and carboetherifications at room temperature have been achieved by a combination of beneficial factors including high aryl diazonium concentration and visible light irradiation. The acceleration of the reaction by visible light irradiation is particularly remarkable against the background that neither the aryldiazonium salt nor the alkene show absorptions in the respective range of wavelength. These observations point to weak charge transfer interactions between diazonium salt and alkene, which are nevertheless able to considerably influence the reaction course. As highly promising perspective, many more aryldiazonium-based radical arylations might benefit from simple light irradiation without requiring a photocatalyst or particular additive.

Iron-catalysed 1,2-aryl migration of tertiary azides

1,2-Aryl migration of α,α-diaryl tertiary azides was achieved by using the catalytic system of FeCl2/N-heterocyclic carbene (NHC) SIPr·HCl. The reaction generated aniline products in good yields after one-pot reduction of the migration-resultant imines.

Thermally Induced Carbohydroxylation of Styrenes with Aryldiazonium Salts

The radical carbohydroxylation of styrenes with aryldiazonium salts has been achieved under mild thermal conditions. A broad range of aryldiazonium salts was tolerated, and the reaction principle based on a radical–polar crossover mechanism could be exten

Doing the methylene shuffle - Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine

S-Trityl l-cysteine (STLC) is an inhibitor of the mitotic kinesin Eg5 with potential as an antimitotic chemotherapeutic agent. We previously reported the crystal structure of the ligand-protein complex, and now for the first time, have quantified the interactions using a molecular dynamics based approach. Based on these data, we have explored the SAR of the trityl head group using the methylene shuffle strategy to expand the occupation of one of the hydrophobic pockets. The most potent compounds exhibit strong (100 nM) inhibition of Eg5 in the basal ATPase assay and inhibit growth in a variety of tumour-derived cell lines.