110044-33-2Relevant academic research and scientific papers
Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs
Maianti, Juan Pablo,Kanazawa, Hiroki,Dozzo, Paola,Matias, Rowena D.,Feeney, Lee Ann,Armstrong, Eliana S.,Hildebrandt, Darin J.,Kane, Timothy R.,Gliedt, Micah J.,Goldblum, Adam A.,Linsell, Martin S.,Aggen, James B.,Kondo, Jiro,Hanessian, Stephen
, p. 2067 - 2073 (2015/02/19)
Aminoglycoside antibiotics are pseudosaccharides decorated with ammonium groups that are critical for their potent broad-spectrum antibacterial activity. Despite over three decades of speculation whether or not modulation of pKa is a viable str
Diastereospecific fluorination of substituted azepanes
Patel, Alpesh Ramanlal,Liu, Fei
, p. 744 - 752 (2013/07/25)
Fluorination of bioactive compounds is an important step in drug discovery and development. Fluorination has been extensively studied in acyclic systems, carbocycles, and fused heterocycles. However, there is no report on fluorination of azepanes. As azep
Total synthesis of aspercyclides a and b via intramolecular oxidative diaryl ether formation
Yoshino, Tatsuya,Sato, Itaru,Hirama, Masahiro
supporting information; experimental part, p. 4290 - 4292 (2012/09/22)
A highly efficient total synthesis of the 11-membered cyclic aspercyclides A (1) and B (2) has been achieved by chemo- and regioselective intramolecular oxidative C-O bond formation from differently substituted diphenols.
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
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Page/Page column 90-91, (2011/04/26)
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (Formula (I)), including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
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Page/Page column 115-116, (2011/04/26)
Compounds having antibacterial activity are disclosed. The compounds have one of the following structures (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3 and Z1 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
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Page/Page column 84, (2011/04/26)
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
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Page/Page column 88-89, (2011/04/26)
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (Formula (I)), including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
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Page/Page column 60-61, (2011/04/26)
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
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Page/Page column 76, (2010/04/28)
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Ql, Q2, Rl, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
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Page/Page column 76, (2010/04/28)
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
