110270-13-8

Basic information

• Product Name: 2-(D-ARABINO-TETRAHYDROXYBUTYL)-4(R)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID
• Synonyms: 2-(D-ARABINO-TETRAHYDROXYBUTYL)-4(R)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID
• CAS NO: 110270-13-8
• Molecular Formula: C₈H₁₅NO₆S
• Molecular Weight: 253.273
• Mol File: 110270-13-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 654.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.624±0.06 g/cm3(Predicted)
• PKA: 1.97±0.40(Predicted)
• CAS DataBase Reference: 2-(D-ARABINO-TETRAHYDROXYBUTYL)-4(R)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(D-ARABINO-TETRAHYDROXYBUTYL)-4(R)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID(110270-13-8)
• EPA Substance Registry System: 2-(D-ARABINO-TETRAHYDROXYBUTYL)-4(R)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID(110270-13-8)

Safety Data

• Hazardous Substances Data: 110270-13-8(Hazardous Substances Data)

Usage

Description

2-(D-ARABINO-TETRAHYDROXYBUTYL)-4(R)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID is a thiazolidine derivative with a tetrahydroxybutyl substituent and a D-arabino configuration. It is a chemical compound with potential biological activities, including the inhibition of advanced glycation end products (AGEs) formation and anti-inflammatory properties.

Uses

Used in Pharmaceutical Industry:
2-(D-ARABINO-TETRAHYDROXYBUTYL)-4(R)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID is used as a potential inhibitor of advanced glycation end products (AGEs) for its role in preventing or treating conditions associated with AGEs, such as diabetes and neurodegenerative diseases.
Used in Anti-inflammatory Applications:
2-(D-ARABINO-TETRAHYDROXYBUTYL)-4(R)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID is used as a potential anti-inflammatory agent for its potential to alleviate chronic inflammatory diseases, which may be beneficial in the development of new therapeutic drugs.
Further research is needed to fully understand the pharmacological properties and potential therapeutic applications of this compound.

Upstream product

• 110270-14-9 (2S,4R,1S,2R,3R)-2-(1,2,3,4-tetrahydroxybutyl)-4-thiazolidincarbonsaeure 
• 10323-20-3 D-Arabinose 
• 52-89-1 l-cysteine hydrochloride 
• 1114-34-7 D-lyxose 
• 52-90-4 L-Cysteine 
• 5328-37-0 L-arabinose 
• 10318-18-0 DL-cysteine hydrochloride 

Downstream Products

• 921-01-7 D-cysteine 

Relevant articles and documents

Heterocyclic Compounds from Sugars, XV: On the Configuration of Chiral C-2 Substituted 1,3-Thiazolidine-4-carboxylic Acids. Chirality Transfer to C-3 of 3,4-Dihydro-1H-pyrrolothiazoles

5-Substituted 3,4-dihydro-pyrrolothiazole-6,7-dicarboxylic acid esters 3 are obtained from 2-substituted-3-acyl-1,3-thiazolidine-4-carboxylic acids, 1 in -cycloaddition reactions via mesoionic oxazolone ("muenchnone") intermediates.The chirali

Thiazolidine-4(R)-carboxylic acids derived from sugars: Part I, C2-epimerisation in aqueous solutions.

Reactions of L-cysteine (1) with L-xylose, D-ribose, D-lyxose, D-arabnose, D-glucose, L-rhamnose, and-fucose in aqueoes ethanol yielded crystalline 2(S)-(polihydroxyalkyl)thiazolidine-4(R)-carboxylic acids.Likewise, glycolaldehyde and L-glyceraldehyde, D-xylose, L-arabinose, D-mannose, D-galactose, and D-fucose gave crystalline 2(R),4(R) epimers.The reaction of 1 and D-glycerinaldehyde gave a syrup mixture of 2(S),4(R) and 2(R),4(R) compounds.The same substrates, but with no ethanol present, gave the 2(S),4(R) epimers for glycolaldehyde, L-xylose, L-fucose, and L-arabinose, and the 2(R),4(R) epimers for D-lyxose, L-rhamnose, D-mannose, Dgalactose, and D-fucose.The reactions of D-ribose, D-arabinose, D-xylose, and D-glucose gave sirupy mixtures of epimers.The crystalline reaction products, when dissolved in water, undergo rapid epimerisation as reflected by mutarotation and changes in the 1H- and 13C-n.m.r. spectra.