110333-86-3

Upstream product

• 6335-93-9 1-naphthalen-2-yl-3-phenyl-thiourea 
• 17931-25-8 2-chloronaphtho<2,1-d>thiazole 
• 62-53-3 aniline 
• 1636-33-5 2-naphthyl isothiocyanate 
• 1166-32-1 N,N'-di(2-naphthyl)thiourea 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 103-85-5 monophenylthiourea 

Downstream Products

• 111091-98-6 N-methyl-N-phenylnaphtho[2,1-d]thiazol-2-amine 
• 111091-99-7 (3-methyl-3H-naphtho[2,1-d]thiazol-2-ylidene)-phenyl-amine 

Relevant academic research and scientific papers

Visible-light-induced regioselective cross-dehydrogenative coupling of 2-isothiocyanatonaphthalenes with amines using molecular oxygen

An efficient and eco-friendly protocol for the construction of naphtho[2,1-d]thiazol-2-amines through visible-light photoredoxcatalyzed C(sp2)-H/S-H cross-dehydrogenative coupling reactions between 2-isothiocyanatonaphthalenes and amines was established. In this reaction, the new C-N and C-S bonds are formed simultaneously in a single step. This new method provides a straightforward approach for constructing valuable sulfur-containing compounds.[Figure not available: see fulltext.].

Visible-Light-Initiated Cascade Reaction of 2-Isothiocyanatonaphthalenes and Amines under Additive- and External Photocatalyst-Free and Mild Conditions

A simple and efficient visible-light-initiated cascade reaction of 2-isothiocyanatonaphthalenes and amines with ambient dioxygen as the sole oxidant under additive-, external photocatalyst-free and ambient conditions was developed. 38 Examples of N-substituted naphtho[2,1-d]thiazol-2-amines were regioselectively constructed in good to excellent yields. (Figure presented.).

Synthesis method and application of 2-aminonaphtho [2, 1-d] thiazole compound promoted by visible light

The invention relates to the technical field of organic synthesis, in particular to a synthesis method and application of a 2-aminonaphtho [2, 1-d] thiazole compound promoted by visible light. Substituted isothiocyanate-2-naphthyl ester and substituted organic amine are used as raw materials, an organic dye is used as a photocatalyst, and under the conditions of an organic solvent and oxygen, a reaction solution is irradiated with near blue light to synthesize the 2-aminonaphtho [2, 1-d] thiazole compound. The synthesis method provided by the invention is suitable for synthesizing and screening anticancer or antiviral biological medicine lead compounds. The synthesis method provided by the invention is simple in preparation process and device, harsh synthesis conditions are not needed, thereaction can be completed in one step, and the synthesis method is suitable for synthesizing various 2-aminonaphtho [2, 1-d] thiazole compounds and derivatives, has relatively high universality to various functional groups on aromatic rings, and has no special limitation on the 2-aminonaphtho [2, 1-d] thiazole compound and the number and types of substituents of organic amine.

Photocatalytic synthesis method of N-arylnaphtho[2, 1-d]thiazol-2-amine

The invention discloses a photocatalytic synthesis method of N-arylnaphtho[2, 1-d]thiazol-2-amine. The method comprises the following step: carrying out a one-pot reaction on 2-naphthyl isothiocyanateand aromatic primary amine in an oxygen-containing atmosphere under the ultraviolet irradiation condition of 385-390 nm to generate the N-arylnaphtho[2, 1-d] thiazol-2-amine compound. The method hasthe advantages of mild conditions, simplicity in operation, environmental protection, easily available raw materials, excellent compatibility of substrate functional groups, high reaction yield and the like.

Metal-free synthesis of 2-aminobenzothiazoles via aerobic oxidative cyclization/dehydrogenation of cyclohexanones and thioureas

A metal-free process for the synthesis of 2-aminobenzothiazoles from cyclohexanones and thioureas has been developed using catalytic iodine and molecular oxygen as the oxidant under mild conditions. Various 2-aminobenzothiazoles, 2-aminonaphtho[2,1-d]thiazoles, and 2-aminonaphtho[1,2-d] thiazoles were prepared via this method in satisfactory yields.