6335-93-9

Usage

Chemical structure

Thiourea derivative with a naphthyl and a phenyl group attached to the nitrogen and sulfur atoms, respectively.

Potential applications

Medicinal chemistry
Agriculture
Materials science

Biological activity

Antifungal properties
Antibacterial properties

Pharmaceutical development

Potential candidate for the development of new pharmaceuticals due to its antifungal and antibacterial properties.

Agrochemical development

Potential candidate for the development of new agrochemicals due to its antifungal and antibacterial properties.

Material synthesis

Unique structural features make it a promising candidate for the synthesis of novel materials with specific properties.

Further research

More research is needed to explore its full potential and possible applications in different industries.

InChI:InChI=1/C17H14N2S/c20-17(18-15-8-2-1-3-9-15)19-16-11-10-13-6-4-5-7-14(13)12-16/h1-12H,(H2,18,19,20)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 91-59-8 naphthalen-2-ylamine 
• 1636-33-5 2-naphthyl isothiocyanate 
• 62-53-3 aniline 
• 67-66-3 chloroform 
• 1166-32-1 N,N'-di(2-naphthyl)thiourea 

Downstream Products

• 1636-33-5 2-naphthyl isothiocyanate 
• 110333-86-3 N-phenylnaphtho[2,1-d]thiazol-2-amine 
• 6299-42-9 NSC 44661 
• 7669-45-6 (3-naphthalen-2-yl-4-oxo-2-phenylimino-thiazolidin-5-yl)-acetic acid 
• 111022-28-7 1-Naphthalen-2-yl-3-phenyl-thiourea; compound with 2,3-dicyano-but-2-enedinitrile 
• 114853-72-4 1,3-dihydro-1-(2'-naphthyl)-3-phenyl-2-thioxo-2H,5H-pyrimidine-4,6-dione 
• 103-72-0 phenyl isothiocyanate 
• 62-53-3 aniline 
• 91-59-8 naphthalen-2-ylamine 
• 3394-04-5 naphthalen-2-yl-thiourea 
• 1056051-20-7 [4-(3,4-dimethoxyphenyl)-thiazol-2-yl]-naphthalen-2-yl-amine 
• 111091-98-6 N-methyl-N-phenylnaphtho[2,1-d]thiazol-2-amine 
• 114854-04-5 1,3-dihydro-5-1-(4',6'-dimethoxypyrimidin-2'-yl)-p-sulphamylbenzeneazo>-1-(2'-naphthyl)-3-phenyl-2-thioxo-2H,5H-pyrimidine-4,6-dione 
• 114900-53-7 1,3-dihydro-5-1-(1'-phenylpyrazol-5'-yl)-p-sulphamylbenzeneazo>-1-(2'-naphthyl)-3-phenyl-2-thioxo-2H,5H-pyrimidine-4,6-dione 

Relevant academic research and scientific papers

Thiocarbonyl Surrogate via Combination of Sulfur and Chloroform for Thiocarbamide and Oxazolidinethione Construction

An efficient and practical thiocarbonyl surrogate via combination of sulfur and chloroform has been developed. A variety of thiocarbamides and oxazolidinethiones have been established, including chiral thiourea catalysts and chiral oxazolidinethione auxiliaries with high selectivity. Meanwhile, pesticides Diafenthiuron (an acaricide), ANTU (a rodenticide), and Chloromethiuron (an insecticide) were practically synthesized through this method in gram scale. Dicholorocarbene, as the key intermediate, was further confirmed via a carbene-trapping control experiment.

2-aminothiazoles as therapeutic leads for prion diseases

2-Aminothiazoles are a new class of small molecules with antiprion activity in prion-infected neuroblastoma cell lines (J. Virol. 2010, 84, 3408). We report here structure-activity studies undertaken to improve the potency and physiochemical properties of 2-aminothiazoles, with a particular emphasis on achieving and sustaining high drug concentrations in the brain. The results of this effort include the generation of informative structure-activity relationships (SAR) and the identification of lead compounds that are orally absorbed and achieve high brain concentrations in animals. The new aminothiazole analogue (5-methylpyridin-2-yl)-[4-(3-phenylisoxazol-5-yl)-thiazol-2-yl]-amine (27), for example, exhibited an EC50 of 0.94 μM in prion-infected neuroblastoma cells (ScN2a-cl3) and reached a concentration of ～25 μM in the brains of mice following three days of oral administration in a rodent liquid diet. The studies described herein suggest 2-aminothiazoles as promising new leads in the search for effective therapeutics for prion diseases.