110349-26-3

Basic information

• Product Name: t-Butyl2-iodobenzoate
• Synonyms: t-Butyl2-iodobenzoate;tert-Butyl 2-iodobenzoate
• CAS NO: 110349-26-3
• Molecular Formula: C₁₁H₁₃IO₂
• Molecular Weight: 304.12419
• Mol File: 110349-26-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 142 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.528±0.06 g/cm3(Predicted)
• CAS DataBase Reference: t-Butyl2-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: t-Butyl2-iodobenzoate(110349-26-3)
• EPA Substance Registry System: t-Butyl2-iodobenzoate(110349-26-3)

Safety Data

• Hazardous Substances Data: 110349-26-3(Hazardous Substances Data)

Usage

General Description

t-Butyl 2-iodobenzoate is an organic compound with the chemical formula C11H13IO2. It is a white to off-white crystalline powder that is commonly used as a reagent in organic synthesis, particularly in the synthesis of aromatic compounds. t-Butyl 2-iodobenzoate is a versatile chemical that can be used as a source of the t-butyl ester group in organic reactions. It is also used as a precursor in the synthesis of pharmaceuticals and agrochemicals. Additionally, t-Butyl 2-iodobenzoate is a useful compound in the field of medicinal chemistry due to its potential as a building block for drug development. However, it is important to handle this chemical with care as it may be hazardous if not used properly.

Upstream product

• 774-65-2 benzoic acid tert-butyl ester 
• 609-67-6 2-Iodobenzoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 88-67-5 2-Iodobenzoic acid 
• 115-11-7 isobutene 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 114772-36-0 tert-butyl 4'-methyl-2-biphenylcarboxylate 
• 596-29-2 3,3-diphenyl-2-benzofuran-1(3H)-one 
• 5398-11-8 3-phenylphthalide 
• 494747-17-0 tert-butyl 2-(phenylethynyl)benzoate 
• 1001350-42-0 C(CH₃)3O₂CC₆H₄P(CH₃)(C₆H₅)(BH₃) 
• 1394130-38-1 C₃₇H₄₃N₅OSSi 
• 1394130-37-0 C₃₇H₄₂N₄O₂Si 
• 1401319-70-7 2-((E)-2-ethoxycarbonylvinyl)benzoic acid tert-butyl ester 
• 1408444-65-4 2-iodo-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one 
• 1408445-57-7 3-phenyl-2-(phenylethynyl)-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one 
• 1408445-60-2 (E)-3-phenyl-2-styryl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one 
• 1408445-62-4 2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one 
• 1408443-68-4 tert-butyl 2-(3-hydroxy-3,3-diphenylprop-1-yn-1-yl)benzoate 

Relevant articles and documents

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

We report SAR studies on a novel non-peptidic bombesin receptor subtype-3 (BRS-3) agonist lead series derived from high-throughput screening hit RY-337. This effort led to the discovery of compound 22e with significantly improved potency at both rodent and human BRS-3.

Palladium(II)-Catalyzed Direct Access to Indeno[1,2-c]isochromen-5(11H)-Ones via Intramolecular Oxypalladation-Initiated Cascade Process

A palladium(II)-catalyzed cascade approach was established for the synthesis of indeno[1,2-c]isochromen-5(11H)-ones starting from 2-alkynyl tert-butyl benzoates bearing a pendant α,β-unsaturated carbonyl moiety in high yields (up to 99%) under mild condit

Metal-Free Synthesis of 4-Chloroisocoumarins by TMSCl-Catalyzed NCS-Induced Chlorinative Annulation of 2-Alkynylaryloate Esters

4-Chloroisocoumarins can be conveniently prepared from 2-alkynylaryloate esters via the activation of alkynes by electrophilic chlorine, generated in situ from N-chlorosuccinimide (NCS) in the presence of 10 mol % trimethylsilyl chloride (TMSCl), which leads to 6-endo-dig-selective chlorinative annulation to give the desired products in moderate to quantitative yields. The procedure employs readily available reagents and can be conveniently carried out on a wide scope of substrates under mild conditions (0 °C to rt). Furthermore, the reaction is scalable for gram-scale preparation of 4-chloroisocoumarins. Additionally, 4-bromo- and 4-iodoisocoumarins can be prepared in moderate to good yields by replacing NCS with N-bromosuccinimide (NBS) and N-iodosuccinimide (NIS), respectively.