110349-26-3

Usage

Uses

Used in Organic Synthesis:
t-Butyl 2-iodobenzoate is used as a reagent for the synthesis of aromatic compounds, providing a reliable source of the t-butyl ester group in organic reactions.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, t-Butyl 2-iodobenzoate is utilized as a precursor in the synthesis of various drugs, contributing to the development of new medicinal compounds.
Used in Agrochemical Synthesis:
t-Butyl 2-iodobenzoate also serves as a precursor in the synthesis of agrochemicals, playing a role in the development of agricultural products.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, t-Butyl 2-iodobenzoate is used as a building block for drug development, offering potential in the creation of new therapeutic agents.

Upstream product

• 774-65-2 benzoic acid tert-butyl ester 
• 609-67-6 2-Iodobenzoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 88-67-5 2-Iodobenzoic acid 
• 115-11-7 isobutene 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 114772-36-0 tert-butyl 4'-methyl-2-biphenylcarboxylate 
• 596-29-2 3,3-diphenyl-2-benzofuran-1(3H)-one 
• 5398-11-8 3-phenylphthalide 
• 18019-56-2 3-methyl-3-phenylphthalide 
• 774-65-2 benzoic acid tert-butyl ester 
• 137786-59-5 3-hexyl-3H-isobenzofuran-1-one 
• 494747-17-0 tert-butyl 2-(phenylethynyl)benzoate 
• 1001350-42-0 C(CH₃)3O₂CC₆H₄P(CH₃)(C₆H₅)(BH₃) 
• 88-67-5 2-Iodobenzoic acid 
• 65-85-0 benzoic acid 
• 1123890-52-7 tert-butyl {[⁽²⁾H₅]-phenyl(4-bromophenyl)phosphinyl}benzoate 
• 1394130-38-1 C₃₇H₄₃N₅OSSi 
• 1394130-37-0 C₃₇H₄₂N₄O₂Si 
• 1401319-70-7 2-((E)-2-ethoxycarbonylvinyl)benzoic acid tert-butyl ester 

Relevant academic research and scientific papers

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

We report SAR studies on a novel non-peptidic bombesin receptor subtype-3 (BRS-3) agonist lead series derived from high-throughput screening hit RY-337. This effort led to the discovery of compound 22e with significantly improved potency at both rodent and human BRS-3.

Palladium(II)-Catalyzed Direct Access to Indeno[1,2-c]isochromen-5(11H)-Ones via Intramolecular Oxypalladation-Initiated Cascade Process

A palladium(II)-catalyzed cascade approach was established for the synthesis of indeno[1,2-c]isochromen-5(11H)-ones starting from 2-alkynyl tert-butyl benzoates bearing a pendant α,β-unsaturated carbonyl moiety in high yields (up to 99%) under mild condit

Lipshutz-type bis(amido)argentates for directed: Ortho argentation

Bis(amido)argentate (TMP)2Ag(CN)Li2 (3, TMP-Ag-ate; TMP = 2,2,6,6-tetramethylpiperidido) was designed as a tool for chemoselective aromatic functionalization via unprecedented directed ortho argentation (DoAg). X-Ray crystallographic analysis showed that 3 takes a structure analogous to that of the corresponding Lipshutz cuprate. DoAg with this TMP-Ag-ate afforded multifunctional aromatics in high yields in processes that exhibited high chemoselectivity and compatibility with a wide range of functional groups. These included organometallics- A nd transition metal-susceptible substituents such as methyl ester, aldehyde, vinyl, iodo, (trifluoromethanesulfonyl)oxy and nitro groups. The arylargentates displayed good reactivity with various electrophiles. Chalcogen (S, Se, and Te) installation and azo coupling reactions also proceeded efficiently.

SILICON-CONTAINING HETEROCYCLIC COMPOUND, AND QUENCHER

Quenchers of the related art do not have a quenching ability high enough to sufficiently inhibit the emission of fluorescence from fluorescence compounds. Therefore, the present invention aims to provide a quencher which can sufficiently quench the fluore

Metal-Free Synthesis of 4-Chloroisocoumarins by TMSCl-Catalyzed NCS-Induced Chlorinative Annulation of 2-Alkynylaryloate Esters

4-Chloroisocoumarins can be conveniently prepared from 2-alkynylaryloate esters via the activation of alkynes by electrophilic chlorine, generated in situ from N-chlorosuccinimide (NCS) in the presence of 10 mol % trimethylsilyl chloride (TMSCl), which leads to 6-endo-dig-selective chlorinative annulation to give the desired products in moderate to quantitative yields. The procedure employs readily available reagents and can be conveniently carried out on a wide scope of substrates under mild conditions (0 °C to rt). Furthermore, the reaction is scalable for gram-scale preparation of 4-chloroisocoumarins. Additionally, 4-bromo- and 4-iodoisocoumarins can be prepared in moderate to good yields by replacing NCS with N-bromosuccinimide (NBS) and N-iodosuccinimide (NIS), respectively.

A unified synthesis of cyclic ethers or lactones via Pd-catalyzed intramolecular O-functionalization of sp3C[sbnd]H bonds

A general approach for the synthesis of lactones or cyclic ethers via Pd-catalyzed C(sp3)[sbnd]H activation and intramolecular C[sbnd]O functionalization starting from carboxylic acids or alcohols using the bidentate directing group has been de

Catalyst-Free Synthesis of Borylated Lactones from Esters via Electrophilic Oxyboration

A catalyst-free oxyboration reaction of alkynes is developed. The resulting borylated isocoumarins and 2-pyrones are isolated as boronic acids, pinacolboronate esters, or potassium organotrifluoroborate salts, providing a variety of bench-stable organobor

Facile synthesis of 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′- ones via iodine-promoted cascade cyclization

A novel and efficient synthetic approach to substituted 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′-ones has been developed via an iodine-promoted cascade cyclization of 2-(3-hydroxy-3,3-diarylprop-1-yn- 1-yl)benzoates. This sequential cascade process is concisely conducted at room temperature. Subsequent palladium-catalyzed Sonogashira, Suzuki, and Heck reactions of the resulting iodides proceed smoothly in good yields.

Palladium(ii)-catalysed tandem cyclisation of electron-deficient aromatic enynes

A novel palladium(ii) catalysed tandem cyclisation of substituted 2-alkenylphenyl alkynones gives substituted 2-vinyl indenones and 6,5,6-fused tricyclic lactone skeletons (pyrones), in one-pot. Wagner-Meerwein-like rearrangements were observed which occu

Spirolactonized Si-rhodamine: A novel NIR fluorophore utilized as a platform to construct Si-rhodamine-based probes

Spirolactonized Si-rhodamine was prepared as a platform to construct Si-rhodamine-based probes by following the design strategy widely used in rhodamine systems. Among them, the reaction-based probe SiR-Hg was operated for NIR sensing and bioimaging of Hg