110461-20-6

Upstream product

• 1003-29-8 2-pyrrole aldehyde 
• 100063-06-7 2-hydroxy-2-phenyl-1-(1H-pyrrol-2-yl)ethanone 
• 100-52-7 benzaldehyde 
• 1398122-49-0 C₁₆H₁₇NO₄ 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 32597-34-5 1H-pyrrole-2-carbaldehyde oxime 
• 35563-07-6 2-styrylpyrrole 
• 109-97-7 pyrrole 
• 614-16-4 Benzoylacetonitrile 

Relevant academic research and scientific papers

Ruthenium/dendrimer complex immobilized on silica-functionalized magnetite nanoparticles catalyzed oxidation of stilbenes to benzil derivatives at room temperature

A new ruthenium/dendrimer complex stabilized on the surface of silica-functionalized nano-magnetite was fabricated and well characterized. The nano-catalyst showed good activity in the synthesis of benzil derivatives via the oxidation of stilbenes with high turnover frequency (TOF) at room temperature. Moreover, the catalyst could also be reused up to fifteen times without any loss of its activity.

2-bit dicarbonyl substituted pyrrole compound and preparation method thereof

The invention discloses a 2-bit dicarbonyl substituted pyrrole compound and a preparation method thereof, and belongs to the technical field of synthesis of pyrrole derivatives. The technical scheme is that the general structural formula of the 2-bit dicarbonyl substituted pyrrole compound is as shown in the specification. According to the preparation method, 2-bit double-carbonylation of pyrrole is achieved by the aid of one-step cascade reaction, a series of multifunctional 2-bit dicarbonyl substituted pyrrole compounds are synthesized, and the preparation method lays a foundation for further derivatization research of the compound and synthesized pharmaceutical molecules containing pyrrole structures.

Preparation method of 1,2-diketone derivative

The invention discloses a preparation method of a 1,2-diketone derivative. The method comprises the step of enabling a raw material 1,3-diketone derivative to react with a cheap and easily obtained industrial product 2,2,6,6-tetramethyl-1-piperidinyloxy under the catalysis of copper so as to obtain the product 1,2-diketone derivative. According to the preparation method, the 1,3-diketone derivative is used as an initiator, and the raw material is easy to obtain and wide in variety; by utilizing the preparation method, the obtained product types are varied, can be directly used, and can be used for other further reactions; in addition, the reagent dosage in the reaction is less, the pollution is reduced, and the production cost is lowered; moreover the reaction conditions are mild, the reaction operation and the after-treatment process are simple, the reaction time is short, the yield is high, and the preparation method is suitable for industrial production.

A new synthetic route for 1,2-diketo compounds using unexpected C-C bond cleavage by PCC

An efficient method has been established for the preparation of 1,2-diketones by unexpected C-C bond cleavage in 4-keto-2-hydroxy esters using pyridiniumchlorochromate (PCC).

Enantioselective aerobic oxidation of α-hydroxy-ketones catalyzed by oxidovanadium(V) methoxides bearing chiral, N-salicylidene- tert -butylglycinates

Chiral oxidovanadium(V) methoxides prepared from 3,5-disubstituted-N- salicylidene-l-tert-butylglycines and vanadyl sulfate in air-saturated MeOH serve as highly enantioselective catalysts for asymmetric aerobic oxidations and kinetic resolution of alkyl, aryl, and heteroaryl α-hydroxy-ketones with differed α-substituents at ambient temperature in toluene or TBME (tert-butyl methyl ether). The best scenarios involve the use of complexes which bear the tridendate templates derived from 3,5-diphenyl- or 3-o-biphenyl-5-nitro-salicyaldehyde. The kinetic resolution selectivities of the aerobic oxidation process are in the range of 12 to >1000 based on the selectivity factors (krel).

Iron-promoted C - C bond cleavage of 1,3-diketones: A route to 1,2-diketones under mild reaction conditions

A conceptual method for the preparation of 1,2-diketones is reported. The selective C - C bond cleavage of 1,3-diketones affords the 1,2-diketones in high yields under mild reaction conditions in air by the use of FeCl3 as the catalyst and tert-butyl nitrite (TBN) as the oxidant without the use of solvent. The possible reaction mechanism is discussed. This protocol provides an expeditious route to the useful 1,2-diketones.