110511-03-0Relevant academic research and scientific papers
Bridged (β-alkoxyalkyl)CoIII(salen) complexes by intramolecular alkoxycobaltation of unactivated alkenes: New models for coenzyme B12
Blaauw, Rolf,Kingma, Irene E.,Laan, Jan H.,Van Der Baan, Juul L.,Balt, Sijbe,De Bolster, Martinus W. G.,Klumpp, Gerhard W.,Smeets, Wilberth J. J.,Spek, Anthony L.
, p. 1199 - 1210 (2007/10/03)
CoII(salen) derivatives (salen = {N,N′-ethylenebis[salicylideneaminato]}) whose ethanediyl moiety carries an alkenyl side-chain R [R = prop-2-en-1-yl (6a), 2-methylprop-2-en-1-yl (6b), but-2-en-1-yl (6c), but-3-en-1-yl (6d)] react with oxygen a
Intramolecular Alkoxycobaltation: a Novel Route to the Cobalt-Carbon Bond in a Coenzyme B12 Model
Kingma, Irene E.,Wiersma, Marten,Baan, Juul L. van der,Balt, Sijbe,Bickelhaupt, Friedrich,et al.
, p. 832 - 834 (2007/10/02)
Co(II)(salen) derivatives whose ethanediyl moiety carries an ω-alkenyl side chain react with oxygen and methanol or ethanol to give, via interaction between intermediate Co(III) species and the pendant olefin, alkylated products with a β-alkoxy substituted carbon bridge between cobalt and the equatorial ligand; the corresponding intermolecular reaction between Co(II)(salen) and hex-1-ene does not take place.
Synthesis and Biological Properties of α-Mono- and α-Difluoromethyl Derivatives of Tryptophan and 5-Hydroxytryptophan
Schirlin, D.,Gerhart, F.,Hornsperger, J. M.,Hamon, M.,Wagner, J.,Jung, M. J.
, p. 30 - 36 (2007/10/02)
The syntheses of α-mono- amd α-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan are described.In an attempt to selectively regulate serotonin synthesis, α-(mono- and difluoromethyl)tryptophan were tested in vivo as precusors (or prodrugs)
