110550-27-1Relevant academic research and scientific papers
The myo-1,2-diaminocyclitol scaffold defines potent glucocerebrosidase activators and promising pharmacological chaperones for gaucher disease
Trapero, Ana,Llebaria, Amadeu
supporting information; experimental part, p. 614 - 619 (2011/10/08)
A series of cyclitol derivatives with myo-configuration are β-glucocerebrosidase (GCase) inhibitors and show excellent characteristics for the development of pharmacological chaperones for enzyme deficiency in Gaucher disease (GD). The most potent inhibit
Enantio- and diastereodivergent synthetic route to multifarious cyclitols from D-xylose via ring-closing metathesis
Luchetti, Giovanni,Ding, Kejia,D'Alarcao, Marc,Kornienko, Alexander
experimental part, p. 3142 - 3147 (2009/04/06)
Short stereoselective syntheses of various cyclitols, including the derivatives of conduritol B, conduritol F, myo-inositol, and chiro-inositol have been accomplished. The key steps in the syntheses are a ring-closing metathesis process and a diastereodiv
Synthesis of cyclitols via ring-closing metathesis
Kornienko, Alexander,D'Alarcao, Marc
, p. 827 - 829 (2007/10/03)
A convenient synthesis of enantiomerically pure and differentially protected L-chiro- and myo-inositols as well as conduritols B and F from 2,3,4-tri-O-benzyl-D-xylopyranose via ring-closing metathesis is reported. The facile synthesis of conduritol B con
Synthesis of Optically Active Inositol Derivatives Starting from D-Glucurono-6,3-lactone
Watanabe, Yutaka,Mitani, Motohiro,Ozaki, Shoichiro
, p. 123 - 126 (2007/10/02)
D-Glucurono-6,3-lactone was converted to optically active and partially protected inositols.The synthetic strategy involves an efficient conversion of the D-gluco configuration to the L-ido configuration and dials to cyclitols.
