110646-28-1

Upstream product

• 626-34-6 ethyl aminocrotonate 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 155497-48-6 2-chloromethyl-3,5-dicarboethoxy-6-methyl-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine 

Downstream Products

• 160174-50-5 N-benzoyl-N'-<2-<<4-(2,3-dichlorophenyl)-3,5-diethoxycarbonyl-1,4-dihydro-6-methylpyridin-2-yl>methylthio>ethyl>thiourea 
• 1026009-61-9 4-(2,3-Dichloro-phenyl)-2-methyl-6-(2-thioureido-ethylsulfanylmethyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis and in vitro pharmacology of new 1,4-dihydropyridines. 1. 2-(ω-Aminoalkylthiomethyl)-1,4-dihydropyridines as potent calcium channel blockers

The synthesis and in vitro calcium channel blocking activities and binding of 2-(ω-aminoalkylthiomethyl)-4-(substituted)phenyl-1,4- dihydropyridines, by determination of the displacement of [3H]nitrendipine from the calcium channel binding sites on rat cortex have been discussed. It has been shown that increasing the alkyl chain length on the 2-position of the 1,4-dihydropyridine ring from ethyl to pentyl does not affect the calcium channel blocking activity of 3-nitrophenyl substituted dihydropyridines, measured on K+-depolarisation induced contractile responses in rat aorta strips. It did not seem to be important whether the 1,4-dihydropyridines bore 2 identical or different ester moieties on the 3- and 5-position of the 1,4-dihydropyridine ring.