178306-51-9

Basic information

• Product Name: 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
• Synonyms: 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID;alpha-Hydroxy-beta-methoxy-beta-phenylbenzenepropanoic acid;Ambrisentan PI-2
• CAS NO: 178306-51-9
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.298
• EINECS: 1806241-263-5
• Mol File: 178306-51-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 430℃
• Flash Point: 158℃
• Appearance: /
• Density: 1.248
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.24±0.28(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID(178306-51-9)
• EPA Substance Registry System: 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID(178306-51-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 178306-51-9(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid, also known as dexibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce inflammation. It works by inhibiting the enzymes cyclooxygenase-1 and -2, which are involved in the production of inflammatory substances in the body. Dexibuprofen is commonly used to treat conditions such as arthritis, menstrual cramps, and minor aches and pains. It is available in various formulations, including tablets, capsules, and oral suspensions. Like other NSAIDs, dexibuprofen may have potential side effects, including gastrointestinal issues and an increased risk of cardiovascular events. It should be used with caution and under the guidance of a healthcare professional.

InChI:InChI=1/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)

Upstream product

• 119-61-9 benzophenone 
• 124-41-4 sodium methylate 
• 96-34-4 methyl chloroacetate 
• 76527-25-8 3,3-diphenyloxirane-2-carboxylic acid methyl ester 
• 178306-47-3 2-hydroxy-3-methoxy-3,3-diphenylpropionicacid methyl ester 
• 178306-52-0 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid 
• 177036-94-1 ambrisentan 

Downstream Products

• 264123-18-4 (S)-1-[p-chlorophenyl]ethylammonium-(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate 
• 1260633-70-2 (R)-1-(2,4-dichlorophenyl)ethylammonium (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate 
• 1260633-77-9 (S)-1-(2,4-dichlorophenyl)ethylammonium (R)-2-hydroxy-3-methoxy-3,3-diphenylpropionate 
• 177036-94-1 ambrisentan 
• 1260633-84-8 (S)-1-(3-methoxyphenyl)ethylammonium (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate 
• 171714-84-4 darusentan 
• 1106685-61-3 (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid methyl ester 
• 177036-79-2 (S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate 
• 1231755-36-4 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid tertiary butylamine salt 
• 178306-59-7 benzyl 3-methoxy-2-((4-methoxy-6,7-dihydro-5H-cyclopentapyridin-2-yl)oxy)-3,3-diphenylpropionate 
• 1231755-40-0 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid dicyclohexylamine R(+)-phenylethylamine 
• 178306-52-0 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid 
• 177036-94-1 ambrisentan 
• 1240470-84-1 (S)-methyl-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate 

Relevant articles and documents

Synthesis method of 2-hydroxy-3-methoxy-3, 3-diphenyl propionic acid

The invention relates to a synthetic method of 2-hydroxy-3-methoxy-3, 3-diphenyl propionic acid. The invention relates to a preparation method of an ambrisentan key intermediate 2-hydroxy-3-methoxy-3,3-diphenyl propionic acid. According to the preparation

Process for Preparing Ambrisentan

The present invention relates to a method of preparing high purity ambrisentan in a cost-effective and efficient way, and a novel intermediate product used for the method. According to the present invention, optical resolution of 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid can be cost-effectively and efficiently performed using L-prolinamide, and thus crystalline ambrisentan having 99.9% or more of purity and optical purity can be prepared on an industrial scale using the same.COPYRIGHT KIPO 2016

LC-MS/MS characterization of forced degradation products of ambrisentan: Development and validation of a stability-indicating RP-HPLC method

The current study reports the characterization of degradation products of ambrisentan by liquid chromatography-tandem mass spectrometry, and development and validation of a stability-indicating reversed phase high performance liquid chromatographic method