110677-54-8Relevant academic research and scientific papers
SARS-COV-2 INHIBITORS HAVING COVALENT MODIFICATIONS FOR TREATING CORONAVIRUS INFECTIONS
-
, (2021/11/06)
Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.
One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols
Akai, Shuji,Ikawa, Takashi,Masuda, Shigeaki
, (2020/03/23)
Benzynes were selectively generated in situ from phenols and trapped regioselectively with potassium hexamethyldisilazide to form primary anilines following acidic workup. The direct conversion of a phenolic hydroxyl group into a free amino group is a useful method for the preparation of primary aryl amines that are hard to synthesize by using coupling reactions involving phenol derivatives with ammonia. Whereas reactions of ortho- and meta-substituted phenols produced meta-substituted anilines exclusively, those of para-substituted phenols provided ortho-silylanilines.
SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS
-
Page/Page column 99, (2010/02/13)
The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).
1,3-Disubstituted benzazepines as novel, potent, selective neuropeptide Y Y1 receptor antagonists
Murakami, Yasushi,Hara, Hirokazu,Okada, Tetsuo,Hashizume, Hiroshi,Kii, Makoto,Ishihara, Yasunobu,Ishikawa, Michio,Shimamura, Mayumi,Mihara, Shin-Inchi,Kato, Goro,Hanasaki, Kohji,Hagishita, Sanji,Fujimoto, Masafumi
, p. 2621 - 2632 (2007/10/03)
A novel series of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Chemical modification of the R1 and R3 substitue
