57786-33-1Relevant academic research and scientific papers
GLUE DEGRADERS AND METHODS OF USE THEREOF
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, (2021/04/01)
Described herein are glue degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment or prevention of conditions, diseases, and disorders mediated by various target proteins.
SARS-COV-2 INHIBITORS HAVING COVALENT MODIFICATIONS FOR TREATING CORONAVIRUS INFECTIONS
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, (2021/11/06)
Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.
SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS
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Page/Page column 98, (2010/02/13)
The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).
Photochemical nitration by tetranitromethane. Part XL. Regiochemistry of trinitromethyl attachment in the photolysis of benzofuran with tetranitromethane
Butts, Craig P.,Eberson, Lennart,Gonzales-Luque, Remedios,Hartshorn, Chris M.,Hartshorn, Michael P.,Merchan, Manuela,Robinson, Ward T.,Roos, Bjoern O.,Vallance, Claire,Wood, Bryan R.
, p. 984 - 999 (2007/10/03)
The photolysis of the charge-transfer (CT) complex of benzofuran (3) and tetranitromethane in dichloromethane by light exciting only the CT complex (λ>435nm) gives the epimeric pairs of adducts, 3-nitro-2-trinitromethyl-2,3-dihydrobenzofurans 10 and 11, 2-nitro-3-trinitromethyl-2,3-dihydrobenzofurans 12 and 13, 3-hydroxy-2-trinitromethyl-2,3-dihydrobenzofurans 15 and 16, 7-nitro-4-trinitromethyl-4,7-dihydrobenzofurans 17 and 18, nitronic ester 14, dinitro dimers 19 and (21), 6-nitro- and 4-nitro-benzofurans 9 and 22, and 4-trinitromethylbenzofuran 21. In acetonitrile solution similar photolysis gives the same group of products and in addition the epimeric pairs, 2,3-dinitro-2,3-dihydrobenzofurans 4 and 5, 3-hydroxy-2-nitro-2,3-dihydrobenzofurans 6 and 7, and 3-nitrobenzofuran (8). Adducts 10, 11, 15 and 16 are formed by attack of trinitromethanide ion at C2 in the benzofuran radical cation 3·+, adducts 12, 13 and 14 by similar attack at C3, and adducts 17 and 18, and 4-trinitromethylbenzofuran (21) by attack at C4. In 1,1,1,3,3,3-hexafluoropropan-2-ol the analogous photolysis of the CT complex of benzofuran (3) and tetranitromethane gives substantially the dinitro dimers 19 and 20, with small amounts of 3-nitro- (8), 6-nitro- (9), and 4-nitro-benzofuran (22). Reaction of benzofuran (3) with nitrogen dioxide in dichloromethane in the dark gives mainly the 2,3-dinitro adducts 4 and 5, and the 3-hydroxy-2-nitro adducts 6 and 7. High-level quantum chemical calculations (CASSCF/CASPT2), in combination with the valence bond configuration mixing (VBCM) model of the transition state of the radical cation-nucleophile reaction, were performed in order to obtain reactivity indices expressing the reactivity of the various sites of 3·+ toward a nucleophile for comparison with the experimental results. X-ray crystal structures are reported for compounds 5, 8, 14 and 21. Acta Chemica Scandinavica 1997.
