57786-34-2

Usage

Uses

Used in Pharmaceutical Development:
2,3-dihydrobenzofuran-6-amine is used as a key intermediate in the synthesis of pharmaceutical drugs for its potential medicinal properties. Its unique structure allows for the development of new drugs with specific therapeutic effects.
Used in Agrochemical Production:
In the agrochemical industry, 2,3-dihydrobenzofuran-6-amine is used as a precursor in the creation of pesticides and other crop protection agents. Its chemical properties make it suitable for the formulation of effective and targeted agrochemicals.
Used in Organic Synthesis:
2,3-dihydrobenzofuran-6-amine is used as a building block in organic synthesis for the preparation of more complex molecules. Its versatile structure allows for the creation of a wide range of organic compounds with various applications.
Used in Research and Development:
Due to its potential biological activity and pharmacological properties, 2,3-dihydrobenzofuran-6-amine is used in research and development for further exploration of its capabilities and applications in various fields, including medicine and chemistry.

Upstream product

• 911300-51-1 6-nitro-2,3-dihydro-1-benzofuran 
• 42933-43-7 2,3-dihydro-1-benzofuran-5-amine 
• 81926-25-2 5-acetamido-2,3-dihydrobenzo<1,2-b>furan 
• 84594-78-5 6-nitro-2,3-dihydro-1-benzofuran-5-ylamine 
• 7169-34-8 3-oxo-2,3-dihydrobenzo[b]furan 
• 496-16-2 2.3-dihydrobenzofuran 
• 17403-47-3 5-nitro-2,3-dihydro-1-benzofuran 
• 57786-33-1 6-nitrobenzofuran 
• 64209-68-3 6-nitro-1-benzofuran-2-carboxylic acid 
• 69603-99-2 6-nitrobenzofuran-2-carboxylic acid ethyl ester 
• 2460-58-4 2-hydroxy-4-nitrobenzaldehyde 
• 110677-54-8 benzofuran-6-amine 

Downstream Products

• 944447-38-5 6-(2,6-dichlorophenyl)-2-[(2,3-dihydro-6-benzofuranyl)amino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1610766-85-2 C₂₃H₂₆N₄O₄ 
• 110677-54-8 benzofuran-6-amine 

Relevant academic research and scientific papers

SARS-COV-2 INHIBITORS HAVING COVALENT MODIFICATIONS FOR TREATING CORONAVIRUS INFECTIONS

Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.

Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain

In order to discover a novel type of analgesic, we investigated dual activity ligands with TRPV1 antagonism and mu-opioid receptor affinity with the goal of eliciting synergistic analgesia while avoiding the side effects associated with single targeting.

Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template

In an effort to design inhibitors of human glutaminyl cyclase (QC), we have synthesized a library of N-aryl N-(5-methyl-1H-imidazol-1-yl)propyl thioureas and investigated the contribution of the aryl region of these compounds to their structure-activity relationships as cyclase inhibitors. Our design was guided by the proposed binding mode of the preferred substrate for the cyclase. In this series, compound 52 was identified as the most potent QC inhibitor with an IC50 value of 58 nM, which was two-fold more potent than the previously reported lead 2. Compound 52 is a most promising candidate for future evaluation to monitor its ability to reduce the formation of pGlu-Aβ and Aβ plaques in cells and transgenic animals.

4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, R6, B, D, E, G, Q, x and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

6' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1—R4 A, B, D, E, and G are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins

A series of novel tricyclic triazine-di-N-oxides (TTOs) related to tirapazamine have been designed and prepared. A wide range of structural arrangements with cycloalkyl, oxygen-, and nitrogen-containing saturated rings fused to the triazine core, coupled with various side chains linked to either hemisphere, resulted in TTO analogues that displayed hypoxia-selective cytotoxicity in vitro. Optimal rates of hypoxic metabolism and tissue diffusion coefficients were achieved with fused cycloalkyl rings in combination with both the 3-aminoalkyl or 3-alkyl substituents linked to weakly basic soluble amines. The selection was further refined using pharmacokinetic/pharmacodynamic model predictions of the in vivo hypoxic potency (AUCreq) and selectivity (HCD) with 12 TTO analogues predicted to be active in vivo, subject to the achievement of adequate plasma pharmacokinetics.

TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS

The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS

The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).

Tricyclic furo-quinazolinones

Anti-inflammatories and analgesics of the formula SPC1 Wherein X y is --OCH2 CH2 -- or --CH2 CH2 O--, R is lower alkyl, allyl or cycloalkylalkyl and R' is phenyl or phenyl monosubstituted by halo, alkyl, alkoxy