110684-44-1

Upstream product

• 110684-59-8 1-(4-fluorophenyl)-5-phenyl-Δ²-1,2,3-triazoline 
• 3296-02-4 p-azidofluorobenzene 
• 4440-01-1 lithium phenylacetylide 
• 1198463-77-2 (Z)-3-((4-fluorophenyl)amino)-1,3-diphenylprop-2-en-1-one 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 371-40-4 4-fluoroaniline 
• 621-82-9 Cinnamic acid 

Relevant academic research and scientific papers

An Organocatalytic Regiospecific Synthesis of 1,5-Disubstituted 4-Thio-1,2,3-triazoles and 1,5-Disubstituted 1,2,3-Triazoles

Organocatalytic azide-ketone [3+2] cycloaddition (OrgAKC) of a variety of 1-aryl-2-(arylthio)ethanones and 1-alkyl-2-(alkylthio)ethanones with different aryl or alkyl azides is reported in dimethyl sulfoxide or solvent-free under ambient conditions to furnish 1,5-disubstituted 4-thio-1,2,3-triazoles in a regiospecific manner, which are further converted into useful 1,5-disubstituted 1,2,3-triazoles by treatment with Raney Ni at 25 ?C for 1-3 h. Notable features of the OrgAKC reaction include high rate and selectivity, solvent-free conditions, easily available substrates and catalysts, a wide range of synthetic and medicinal applications, and excellent yields generating a vast library of triazoles.

A versatile one-pot synthesis of 4-aryl-1,5-disubstituted 1,2,3-triazoles via 1,3-dipolar cycloaddition followed by Negishi reaction under new conditions

Several derivatives of 4-aryl-1,5-disubstituted 1,2,3-triazole were synthesized in good yields via 1,3-dipolar cycloaddition followed by Negishi reaction under new conditions. Georg Thieme Verlag Stuttgart.

Transition-metal-free regioselective construction of 1,5-diaryl-1,2,3-triazoles through dehydrative cycloaddition of alcohols with aryl azides mediated by SO2F2

A novel, simple and practical method for mild, efficient, cost-effective and regioselective synthesis of highly valuable 1,5-diaryl-1,2,3-triazoles was achieved through dehydrative annulation of readily available alcohols with aryl azides. The reaction proceeded at room temperature, without any metal catalysts, exhibiting excellent compatibility to a large variety of functional groups (>50 examples), resulting in up to quantitative yields. 2019

Copper-catalyzed decarboxylative regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles

A copper-catalyzed decarboxylative regioselective protocol for the synthesis of 1,5-disubstituted 1,2,3-triazoles through direct annulation of cinnamic acids with aryl azides has been developed. This is the first example of 1,5-disubstituted 1,2,3-triazoles, under aerobic conditions using Cu(ii) as the catalyst, which were generally synthesized using a ruthenium(ii) catalyst. The simplicity and regioselectivity of this methodology, complementing to the classical CuAAC catalyzed the synthesis of 1,4-disubstituted 1,2,3-triazoles.

A metal-free multicomponent cascade reaction for the regiospecific synthesis of 1,5-disubstituted 1,2,3-triazoles

About specifics: A method for the regiospecific synthesis of the title compounds through an unprecedented Michael addition/deacylative diazo transfer/cyclization sequence has been established. The simple and practical method can be used for the modification of primary amines including chiral α-amines. The process involves the formation three covalent bonds and the cleavage of two covalent bonds (see scheme, Ts=4-toluenesulfonyl).

Triazolines. 14. 1,2,3-Triazolines and Triazoles, a New Class of Anticonvulsants. Drug Design and Structure-Activity Relationships

Pioneering studies in our laboratory have led to the emergence og the Δ2-1,2,3-triazolines (4,5-dihydro-1H-1,2,3-triazoles) and the closely related 1H-1,2,3-triazoles as a unique family of anticonvulsant agents hitherto unknown.Unlike the tradi