110764-72-2

Basic information

• Product Name: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
• Synonyms: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE;DMT-2'-OMe-Bz-A;N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine;Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)-phenylmethyl]-2'-O-methyl-adenosine;N-(9-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-4-hydroxy-3-Methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzaMide;DMTr-2'-OMe-ABz;5'-DMT-2'-OMe-Bz-A
• CAS NO: 110764-72-2
• Molecular Formula: C₃₉H₃₇N₅O₇
• Molecular Weight: 687.74038
• EINECS: 2017-001-1
• Mol File: 110764-72-2.mol
• Article Data: 6

Chemical Properties

• Appearance: White to Pale Yellow/Powder
• Density: 1.32±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Soluble in chloroform at 50mg/ml
• PKA: 7.87±0.43(Predicted)
• CAS DataBase Reference: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE(110764-72-2)
• EPA Substance Registry System: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE(110764-72-2)

Safety Data

• Hazardous Substances Data: 110764-72-2(Hazardous Substances Data)

Usage

General Description

N6-benzoyl-5'-(dimethoxytrityl)-2'-O-methyladenosine is a chemical compound that features a benzoyl group, a dimethoxytrityl group, and an O-methyladenosine group. It is commonly used in the synthesis of RNA molecules and nucleoside analogs, and it serves as a key building block in the production of modified nucleosides for research purposes. The compound is known for its ability to enhance the stability and binding specificity of RNA molecules, making it a valuable tool in the study of RNA structure and function. Additionally, it has potential applications in the development of novel RNA-based therapeutics and drug delivery systems.

Upstream product

• 2140-79-6 2'-O-methyl adenosine 
• 98-88-4 benzoyl chloride 
• 98-07-7 Benzotrichlorid 
• 100-66-3 methoxybenzene 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 
• 85079-00-1 N⁶-benzoyl-O^2'-methyladenosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 186581-53-3 diazomethane 
• 129666-75-7 6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine 

Downstream Products

• 199581-45-8 Thiocarbonic acid O-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl} ester O-(3-tert-butyl-phenyl) ester 
• 1355047-24-3 C₅₂H₆₀N₇O₉P 
• 118362-06-4 Phosphoric acid (2R,3R,4R,5R)-5-(6-amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester; compound with ammonia 
• 198703-54-7 N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 

Relevant articles and documents

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

TRINUCLEOTIDE MRNA CAP ANALOGS

What is described is a trinucleotide cap analog comprising m7G(5′)p3-N1pN2 for increased efficiency of in vitro transcription of m7G(5′)p3-RNA, wherein m7G is N7-methylguanosine or analog, (5′)p3 is a 5′,5′-triphosphate bridge, and N1 or N2 or both ribonucleotide analogs linked to each other by a phosphate, p, and wherein the trinucleotide cap analog increases the efficiency of in vitro transcription.

An efficient multigram synthesis of monomers for the preparation of novel oligonucleotides containing isosteric non-phosphorous backbones

The facile preparation of two novel classes of nucleoside analogs for the inclusion as dimeric non-phosphorous containing subunits in chime fie backbones has been accomplished. The concise preparation of 3'- formylnucleosides and 5'-O-(N-methylhydroxylamino)-nucleosides is reported.