110764-74-4

Basic information

• Product Name: Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-
• Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-;N4-Benzoyl-5'-O-(4,4'-diMethoxytrityl)-2'-O-Methycytidine;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methylcytidine;5-O-DMT-N4-BENZOYL-2-O-METHYL-CYTIDINE
• CAS NO: 110764-74-4
• Molecular Formula: C₃₈H₃₇N₃O₈
• Molecular Weight: 663.71568
• Mol File: 110764-74-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.58±0.20(Predicted)
• CAS DataBase Reference: Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-(110764-74-4)
• EPA Substance Registry System: Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-(110764-74-4)

Safety Data

• Hazardous Substances Data: 110764-74-4(Hazardous Substances Data)

Usage

Uses

N4-Benzoyl-5''-O-(4,4''-dimethoxytrityl)-2''-O-methycytidine (CAS# 110764-74-4) is a nucleoside used in the synthesis of fluorocarbon oligonucleotide conjugates which allow for the delivery of nucleic acids into human cells. N4-Benzoyl-5''-O-(4,4''-dimethoxytrityl)-2''-O-methycytidine is also used in the preparation of RNA and RNA fragments, such as in the synthesis of capped RNA.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 69304-43-4 1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-N⁴-benzoylcytosine 
• 13089-48-0 N₄-benzoylcytidine 
• 2140-72-9 2'-O-methylcytidine 
• 93-97-0 benzoic acid anhydride 
• 186581-53-3 diazomethane 
• 81246-76-6 4-N-benzoyl-1-(5-O-dimethoxytrityl-β-D-ribofuranosyl)cytosine 
• 74-88-4 methyl iodide 
• 52571-45-6 2'-O-methyl-N⁴-benzoylcytidine 

Downstream Products

• 118380-94-2 C₄₁H₄₆N₅O₁₄P*H₃N 
• 110764-78-8 N4-Benzoyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-methyl cytidine-3'-O-(β-cyanoethyl N,N-diisopropylphosphoramidite) 

Relevant articles and documents

SYNTHESIS OF OLIGONUCLEOTIDES AND RELATED COMPOUNDS

Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or oligonucleotide su

Oligo(2′-O-methylribonucleotides) and their derivatives. II. Synthesis and properties of oligo(2′-O-methylribonucleotides) modified with N-(2-hydroxyethyl)phenazinium and steroid groups at the 5′-terminus

Oligo(2′-O-methylribonucleotides) modified at the 5′-terminus with a steroid (cholesterol or testosterone) or polycyclic aromatic dye N-(2-hydroxyethyl)phenazinium residue were synthesized. It was shown that the introduction of an N-(2-hydroxyethyl)phenazinium moiety into octa(2′-O-methylribonucleotide) increased the melting temperature of the duplex with the d-target by 9°C. The steroid residue, which was attached to the 5′-position of deca(2′-O-methyluridylate) via a phosphodiester linkage, enhanced the stability of the steroid conjugate complexes with d(pA)16 and (pA)16; this effect was stronger with the cholesterol derivative (ΔTm 5 and 8°C, respectively) than with the testosterone derivative(ΔTm 1 and 4°C).

REGIOSPECIFIC CLEAVAGE OF RNA BY RNASE H FROM E. coli IN THE PRESENCE OF A COMPLEMENTARY OLIGONUCLEOTIDE WITH INSERTED ALTERNATING 2'-O-METHYLCYTIDINE RESIDUES

Undecanucleotide dA-dC-dC-dA-Cm-Cm-dG-Cm-dG-Cm-dT (Cm = 2'-O-methylcytidine) was prepared and used as a probe for splitting of 5S rRNA fragment by RNase H (E. coli).It was found that substitution of 2'-deoxycytidine of d(ACCACCGCGCT) by 2'-O-methylcytidin