52571-45-6Relevant articles and documents
Process for the preparation of 2'-O-alkyl purine phosphoramidites
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, (2016/06/29)
2'-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3'-O-phosphoramidites are prepared by alkylating nucleoside precursors, adding suitable blocking groups and phosphitylating. Alkylation is effected on 2,6-diamino-9-(β-D-ribofuranosyl)purine followed by deamination to prepare guanosine 2'-O-alkylated 3'-O-phosphormidites. Alkylation is effected on a dialkyl stannylene derivative of uridine to prepare uridine 2'-O-alkylated 3'-O-phosphormidites. Alkylation is effected directly on cytidine to prepare cytidine 2'-O-alkylated 3'-O-phosphormidites. Alkylation is effected directly on 2,6-diaminopurine to prepare 2,6-diaminopurine 2'-O-alkylated 3'-O-phosphormidites.
SYNTHESIS OF N,O-PROTECTED DERIVATIVES OF 2'-O-METHYLCYTIDINE AND OF 2'-O-METHYL- AND N1-METHYLGUANOSINES
Gladkaya, V. A.,Levitskaya, Z. V.,Shalamai, A. S.,Usenko, L. S.,Dashevskaya, T. A.
, p. 488 - 492 (2007/10/02)
Using selective 3',5'-O-tetraisopropyldisiloxane protection, N-acyl-2'-O-methyl derivatives of cytidine and guanosine and of 2'-O-tetrahydropyranyl-N1-methyl-guanosine have been synthesized.It has been shown that the spatial screening of the am
5'-O-Trityl Group Promoted Directive Effect in the Preparation of 2'-O-Methylribonucleosides
Heikkilae, Jarmo,Bjoerkman, Sven,Oeberg, Bo,Chattopadhyaya, Jyoti
, p. 715 - 718 (2007/10/02)
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