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2'-O-Methylcytidine
Cas No: 2140-72-9
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 2'-O-Methylcytidine supplier in China
Cas No: 2140-72-9
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2'-O-Methylcytidine
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No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
2'-O-Methylcytidine
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Pharmaceutical Grade CAS 2140-72-9 with competitive price
Cas No: 2140-72-9
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
Cytidine, 2'-O-methyl- 2140-72-9
Cas No: 2140-72-9
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
2140-72-9
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2'-O-Methylcytidine
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2'-O-Methylcytidine
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2'-O-methylcytidine China Manufacturer
Cas No: 2140-72-9
USD $ 32.0-50.0 / Kilogram 1 Kilogram 30 Metric Ton/Month XINXIANG AURORA BIOTECHNOLOGY CO., LTD. Contact Supplier

2140-72-9 Usage

Uses

Cytidine analog.

Chemical Properties

White powder

2140-72-9 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (M2317)  2'-O-Methylcytidine  >98.0%(HPLC)(T) 2140-72-9 1g 1,290.00CNY Detail
TCI America (M2317)  2'-O-Methylcytidine  >98.0%(HPLC)(T) 2140-72-9 200mg 480.00CNY Detail

2140-72-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2'-O-methylcytidine

1.2 Other means of identification

Product number -
Other names 2'-OMe Cytidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2140-72-9 SDS

2140-72-9Synthetic route

3',5'-di-O-acetyl-2'-O-methylcytidine
1085342-86-4

3',5'-di-O-acetyl-2'-O-methylcytidine

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
With ammonia In methanol at 20℃;99%
3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine
97626-19-2

3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃;96%
N4-benzoyl-3',5'-di-O-benzoyl-2'-O-methylcytidine
73793-16-5

N4-benzoyl-3',5'-di-O-benzoyl-2'-O-methylcytidine

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
With ammonia In methanol at 4℃; for 48h;80%
magnesium ethylate
2414-98-4

magnesium ethylate

2,2'-anhydrocytidine hydrochloride

2,2'-anhydrocytidine hydrochloride

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
In methanol for 5h; Reflux;76%
CYTIDINE
65-46-3

CYTIDINE

A

3'-O-Methylcytidine
20594-00-7

3'-O-Methylcytidine

B

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
With tin(ll) chloride In methanol; 1,2-dimethoxyethane for 0.333333h; Ambient temperature;A 14%
B 69%
dibutyldimethoxytin In methanol Mechanism;
dibutyldimethoxytin In methanol
trimethylsulphonium hydroxide
17287-03-5

trimethylsulphonium hydroxide

CYTIDINE
65-46-3

CYTIDINE

A

3'-O-Methylcytidine
20594-00-7

3'-O-Methylcytidine

B

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

C

N3-methylcytidine
2140-64-9

N3-methylcytidine

Conditions
ConditionsYield
With copper acetylacetonate In N,N-dimethyl-formamide at 70℃; for 1h;A 22%
B 60%
C 3%
In N,N-dimethyl-formamide at 70℃; for 1h;A 7%
B 28%
C 13%
With copper acetylacetonate In N,N-dimethyl-formamide at 70℃; for 1h; Product distribution; without metallo-organic compound;
In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Title compound not separated from byproducts;A 7 % Spectr.
B 28 % Spectr.
C 13 % Spectr.
In methanol; N,N-dimethyl-formamide at 70℃; Title compound not separated from byproducts;A n/a
B 28 % Spectr.
C 13 % Spectr.
trimethylsulphonium hydroxide
17287-03-5

trimethylsulphonium hydroxide

CYTIDINE
65-46-3

CYTIDINE

A

3'-O-Methylcytidine
20594-00-7

3'-O-Methylcytidine

B

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
With magnesium(II) acetylacetonate In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Product distribution; absence of metal ion;A 2%
B 43%
With magnesium(II) acetylacetonate In methanol; N,N-dimethyl-formamide at 70℃; for 1h;A 2%
B 43%
trimethylphenylammonium hydroxide
1899-02-1

trimethylphenylammonium hydroxide

CYTIDINE
65-46-3

CYTIDINE

A

3-methyluridine
2140-69-4

3-methyluridine

B

3'-O-Methylcytidine
20594-00-7

3'-O-Methylcytidine

C

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃;A n/a
B 3 % Spectr.
C 24%
In N,N-dimethyl-formamide at 100℃;A 22 % Spectr.
B 4 % Spectr.
C 21%
1-methyl-1-nitrosourea
684-93-5

1-methyl-1-nitrosourea

CYTIDINE
65-46-3

CYTIDINE

A

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

B

N3-methylcytidine
2140-64-9

N3-methylcytidine

Conditions
ConditionsYield
With borax In water; formamide at 50℃; for 18h;A 5%
B n/a
CYTIDINE
65-46-3

CYTIDINE

methyl iodide
74-88-4

methyl iodide

A

3'-O-Methylcytidine
20594-00-7

3'-O-Methylcytidine

B

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
With sodium hydride 1) DMF, 0 deg C, 45 min, 2a) 0 deg C, 2.5 h, 2b) r.t., 1 h; Multistep reaction. Yields of byproduct given;
With sodium hydride 1) DMF, 0 deg C, 45 min, 2a) 0 deg C, 2.5 h, 2b) r.t., 1 h; Yield given. Multistep reaction;
N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-3-methyl-butyramide

N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-3-methyl-butyramide

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
With dichloro-acetic acid; ammonium hydroxide
Trimethyl borate
121-43-7

Trimethyl borate

2,2'-anhydro-1-(β-D-arabinofuranosyl)cytosine acetate
10212-28-9

2,2'-anhydro-1-(β-D-arabinofuranosyl)cytosine acetate

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
With methanol; boron trifluoride for 48h; Ring cleavage; Heating;
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-4-(2-nitrophenyl)-2-pyrimidinone
108782-90-7

1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-4-(2-nitrophenyl)-2-pyrimidinone

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / silver oxide / acetone / 72 h / 20 °C
2: 75 percent / ammonia / tetrahydrofuran
3: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone
110567-19-6

1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / ammonia / tetrahydrofuran
2: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
4-(2-Nitro-phenoxy)-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-trimethylsilanyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidin-2-one

4-(2-Nitro-phenoxy)-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-trimethylsilanyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidin-2-one

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.12 g / p-toluenesulfonic acid / CH2Cl2 / 0.03 h / 20 °C
2: 81 percent / silver oxide / acetone / 72 h / 20 °C
3: 75 percent / ammonia / tetrahydrofuran
4: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-O-(trimethylsilyl)uridine
415903-48-9

3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-O-(trimethylsilyl)uridine

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) triethylamine, 2-mesitylenesulfonyl chloride, N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo<2.2.2>octane / 1.) dichloromethane, 30 min, 2.) dichloromethane, 60 min
2: 1.12 g / p-toluenesulfonic acid / CH2Cl2 / 0.03 h / 20 °C
3: 81 percent / silver oxide / acetone / 72 h / 20 °C
4: 75 percent / ammonia / tetrahydrofuran
5: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
uridine
58-96-8

uridine

aqueous H3PO4

aqueous H3PO4

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: pyridine / 20 °C
2: triethylamine / CH2Cl2 / 0.25 h / 20 °C
3: 1.) triethylamine, 2-mesitylenesulfonyl chloride, N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo<2.2.2>octane / 1.) dichloromethane, 30 min, 2.) dichloromethane, 60 min
4: 1.12 g / p-toluenesulfonic acid / CH2Cl2 / 0.03 h / 20 °C
5: 81 percent / silver oxide / acetone / 72 h / 20 °C
6: 75 percent / ammonia / tetrahydrofuran
7: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
69304-38-7

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: triethylamine / CH2Cl2 / 0.25 h / 20 °C
2: 1.) triethylamine, 2-mesitylenesulfonyl chloride, N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo<2.2.2>octane / 1.) dichloromethane, 30 min, 2.) dichloromethane, 60 min
3: 1.12 g / p-toluenesulfonic acid / CH2Cl2 / 0.03 h / 20 °C
4: 81 percent / silver oxide / acetone / 72 h / 20 °C
5: 75 percent / ammonia / tetrahydrofuran
6: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
1,3,5-tri-O-benzoyl-2-O-methyl-α-D-ribofuranose
68045-07-8

1,3,5-tri-O-benzoyl-2-O-methyl-α-D-ribofuranose

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) HMDS, (NH4)2SO4, 2.) SnCl4 / 1.) reflux, overnight, 2.) dichloroethane, reflux, 60 min
2: 80 percent / NH3 / methanol / 48 h / 4 °C
View Scheme
1,3,5-tri-O-benzoyl-α-D-ribofuranoside
22224-41-5

1,3,5-tri-O-benzoyl-α-D-ribofuranoside

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 74 percent / BF3*(C2H5)2O / CH2Cl2 / 0 °C
2: 1.) HMDS, (NH4)2SO4, 2.) SnCl4 / 1.) reflux, overnight, 2.) dichloroethane, reflux, 60 min
3: 80 percent / NH3 / methanol / 48 h / 4 °C
View Scheme
methanol-dichloromethane

methanol-dichloromethane

CYTIDINE
65-46-3

CYTIDINE

methyl iodide
74-88-4

methyl iodide

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

Conditions
ConditionsYield
In N-methyl-acetamide; methanol; ethanol; dichloromethane
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

5'-O-(tert-butyldimethylsilyl)-2'-O-methylcytidine
1171006-87-3

5'-O-(tert-butyldimethylsilyl)-2'-O-methylcytidine

Conditions
ConditionsYield
With pyridine at 20℃;100%
With pyridine at 20℃;100%
With pyridine at 20℃;
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine
97626-19-2

3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine

Conditions
ConditionsYield
With pyridine for 1h; Ambient temperature;98%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

3',5'-O-bis(tert-butyldimethylsilyl)-2'-O-methylcytidine
367511-42-0

3',5'-O-bis(tert-butyldimethylsilyl)-2'-O-methylcytidine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 18h;97.5%
2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

5-bromo-2'-O-methylcytidine
494210-77-4

5-bromo-2'-O-methylcytidine

Conditions
ConditionsYield
With sodium azide; bromoisocyanuric acid monosodium salt In water; acetonitrile at 20℃; for 1.5h;78%
trimethylsulphonium iodide
2181-42-2

trimethylsulphonium iodide

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-4-imino-3-methyl-3,4-dihydro-1H-pyrimidin-2-one
120057-51-4

1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-4-imino-3-methyl-3,4-dihydro-1H-pyrimidin-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 85℃; for 3.5h; Rate constant; Product distribution; Mechanism; other nucleosides and trimethylsulphonium hydroxide;67%
In N,N-dimethyl-formamide at 85℃; for 3.5h;67%
(S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
1337529-56-2

(S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

C22H31N4O9P

C22H31N4O9P

Conditions
ConditionsYield
Stage #1: 2'-O-methylcytidine With isopropylmagnesium chloride In tetrahydrofuran at 0 - 20℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: (S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester In tetrahydrofuran at 0 - 20℃; Schlenk technique; Inert atmosphere;
16.3%
benzoic acid anhydride
93-97-0

benzoic acid anhydride

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

2'-O-methyl-N4-benzoylcytidine
52571-45-6

2'-O-methyl-N4-benzoylcytidine

Conditions
ConditionsYield
In ethanol for 1h; Heating;0.38 g
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

2'-O-methyl-4-N-(9-fluorenylmethoxycarbonyl)cytidine
135944-10-4

2'-O-methyl-4-N-(9-fluorenylmethoxycarbonyl)cytidine

Conditions
ConditionsYield
Yield given. Multistep reaction;
trimethylsulphonium hydroxide
17287-03-5

trimethylsulphonium hydroxide

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

A

1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-4-imino-3-methyl-3,4-dihydro-1H-pyrimidin-2-one
120057-51-4

1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-4-imino-3-methyl-3,4-dihydro-1H-pyrimidin-2-one

B

N4,O2'-dimethylcytidine
13048-95-8

N4,O2'-dimethylcytidine

C

O2',O3'-dimethyl-cytidine
34218-86-5

O2',O3'-dimethyl-cytidine

Conditions
ConditionsYield
In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Title compound not separated from byproducts;A 34 % Spectr.
B 21 % Spectr.
C 8 % Spectr.
2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

5'-O-monomethoxytrityl 2'-O-methyl-N-benzoylcytidine
86872-24-4

5'-O-monomethoxytrityl 2'-O-methyl-N-benzoylcytidine

Conditions
ConditionsYield
Multistep reaction;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

4-Amino-1-((2R,3R,4R,5R)-3-methoxy-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one

4-Amino-1-((2R,3R,4R,5R)-3-methoxy-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one

Conditions
ConditionsYield
In pyridine 0 deg C -> r.t. for 1-2 h;
With pyridine Silylation;
acetic anhydride
108-24-7

acetic anhydride

2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

N4-acetyl-2'-O-methyl cytidine
113886-71-8

N4-acetyl-2'-O-methyl cytidine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; Acetylation;0.94 g
2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

5-bromo-3'-O-[(tert-butyldimethyl)silyl]-2'-O-methylcytidine
444019-26-5

5-bromo-3'-O-[(tert-butyldimethyl)silyl]-2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97.5 percent / imidazole / dimethylformamide / 18 h / 20 °C
2: 83 percent / LiBr; ammonium ceric(IV) nitrate / acetonitrile / 3 h / 20 °C
3: 40 percent / aq. AcOH / 6 h / 50 °C
View Scheme
2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

5-bromo-3',5'-O-bis[(tert-butyldimethyl)silyl]-2'-O-methylcytidine
848860-93-5

5-bromo-3',5'-O-bis[(tert-butyldimethyl)silyl]-2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97.5 percent / imidazole / dimethylformamide / 18 h / 20 °C
2: 83 percent / LiBr; ammonium ceric(IV) nitrate / acetonitrile / 3 h / 20 °C
View Scheme
2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

N4-(4,4'-dimethoxytrityl)-2'-O-methylcytidine
444019-24-3

N4-(4,4'-dimethoxytrityl)-2'-O-methylcytidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97.5 percent / imidazole / dimethylformamide / 18 h / 20 °C
2: DMAP; pyridine / 20 °C
3: 1.8 g / triethylamine trihydrofluoride; triethylamine / tetrahydrofuran / 20 °C
View Scheme
2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

2,2-dimethyl-thiopropionic acid S-(2-{[5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yloxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

2,2-dimethyl-thiopropionic acid S-(2-{[5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yloxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 97.5 percent / imidazole / dimethylformamide / 18 h / 20 °C
2.1: DMAP; pyridine / 20 °C
3.1: 1.8 g / triethylamine trihydrofluoride; triethylamine / tetrahydrofuran / 20 °C
4.1: 1H-tetrazole / acetonitrile / 20 °C
4.2: 3-chloroperbenzoic acid / CH2Cl2 / 20 °C
4.3: aq. AcOH / methanol / 55 °C
View Scheme
2'-O-methylcytidine
2140-72-9

2'-O-methylcytidine

2'-O-methylcytidine-5'-[bis-(S-pivaloyl-2-thioethyl)phosphate]

2'-O-methylcytidine-5'-[bis-(S-pivaloyl-2-thioethyl)phosphate]

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 97.5 percent / imidazole / dimethylformamide / 18 h / 20 °C
2.1: DMAP; pyridine / 20 °C
3.1: 1.8 g / triethylamine trihydrofluoride; triethylamine / tetrahydrofuran / 20 °C
4.1: 1H-tetrazole / acetonitrile / 20 °C
4.2: 3-chloroperbenzoic acid / CH2Cl2 / 20 °C
4.3: 22 percent / aq. AcOH / methanol / 55 °C
View Scheme

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