110795-28-3

Upstream product

• 127-09-3 sodium acetate 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 108-24-7 acetic anhydride 
• 583-53-9 2,3-dibromobenzene 
• 28839-73-8 (E)-3-[2-{(E)-2-ethoxycarbonylvinyl}phenyl]acrylic acid ethyl ester 

Downstream Products

• 177429-63-9 1,2-bis-(3-bromopropyl)benzene 
• 143260-95-1 3-[2-(3-hydroxypropyl)phenyl]propanol 
• 55444-18-3 3-[2-(2-ethoxycarbonyl-ethyl)-phenyl]-propionic acid ethyl ester 
• 856076-26-1 3,3'-o-phenylene-di-propionic acid diamide 
• 91-20-3 naphthalene 
• 871876-94-7 3,3'-(1,2-phenylene)dipropionic acid 
• 28839-73-8 (E)-3-[2-{(E)-2-ethoxycarbonylvinyl}phenyl]acrylic acid ethyl ester 
• 115984-41-3 (E)-3-[2-{(E)-2-methoxycarbonylvinyl}phenyl]acrylic acid methyl ester 

Relevant academic research and scientific papers

Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3′-arylenebisacryloyl group as a linker

We synthesized the novel seco cyclopropa[c]pyrrolo[3,2-e]indole (CPI) bisalkylators and evaluated their antitumor activity. Among these derivatives, 11a (AT-760), in which the two seco 3-methoxycarbonyl-2-trifluoromethyl CPI (MCTFCPI) moieties are connected with a 3,3′-(1,4-phenylene)bisacryloyl group, was found to exhibit more potent cytotoxicity and antitumor activity against HeLaS3 human uterine cervix carcinoma cells and Colon 26 adenocarcinoma cells, respectively, than 8 (bizelesin, U-77,779). It also appeared that compound 11a exhibits improved in vivo efficacy in the human colon CX-1 model when compared to either compound 8 or mitomycin C (MMC). Efficacious doses for 11a were found to be 2-fold lower than those for 8.

Perkin-Synthese mit Caesiumacetat

This work demonstrates that significant higher yields and shorter reaction times in the Perkin synthesis of cinnamic acids are obtained in all cases investigated, when sodium acetate is replaced by caesium acetate.The caesium variant of the Perkin reaction described here should therefore be generally preferred