1109284-40-3

Basic information

• Product Name: (1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol
• Synonyms: (1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol
• CAS NO: 1109284-40-3
• Molecular Weight: 151.156
• Mol File: 1109284-40-3.mol

Chemical Properties

• Boiling Point: 205.4±40.0 °C(Predicted)
• Density: 1.23±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol(1109284-40-3)
• EPA Substance Registry System: (1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol(1109284-40-3)

Safety Data

• Hazardous Substances Data: 1109284-40-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure, including fluorine substitutions and an amino group, allows for specific reactivity and functional group manipulations that can be exploited in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol is used as a starting material or intermediate in the development of new drugs. Its distinct stereochemistry and functional groups may confer specific biological activities or improve the pharmacokinetic properties of drug candidates. Researchers can explore its potential in the treatment of various diseases by incorporating it into the molecular design of new therapeutic agents.
Further study and development of (1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol could reveal additional applications in different fields, taking advantage of its unique structural elements and properties.

Upstream product

• 6705-49-3 7-oxabicyclo[4.1.0]heptan-2-one 
• 1109284-38-9 2,2-difluoro-7-oxabicyclo[4.1.0]heptane 
• 6705-49-3 7-oxabicyclo[4.1.0]heptan-2-one 
• 1109284-39-0 (1S,6R)-2,2-difluoro-6-[[(1R)-1-phenylethyl]amino]cyclohexanol 

Downstream Products

• 1109284-41-4 tert-butyl N-[(1R,2S)-3,3-difluoro-2-hydroxycyclohexyl]carbamate 
• 1439907-22-8 2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)-4-(quinolin-3-ylamino)pyrimidin-5-carboxamide 
• 1207557-06-9 (1S,6R)-6-((tert-butoxycarbonyl)amino)-2,2-difluorocyclohexyl trifluoromethanesulfonate 
• 1109284-37-8 tert-butyl N-[(1R,2R)-2-amino-3,3-difluorocyclohexyl]carbamate 
• 1439905-72-2 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide 
• 1314893-26-9 N-((1R,6R)-6-amino-2,2-difluorocyclohexyl)-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophene-2-carboxamide 
• 1109284-45-8 tert-butyl N-[(1R,2R)-2-azido-3,3-difluorocyclohexyl]carbamate 

Relevant articles and documents

HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF

The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, useful as IRAK inhibitors.

Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties

Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. This manuscript outlines efforts to optimize a pyrazolopyrimidine series of MARK in

SELECTIVE KINASE INHIBITORS

Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS

The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS

The invention encompasses imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES

Compounds of the following formula (I) are inhibitors of microtubule affinity regulating kinase, and hence find use in the treatment of neurodegenerative diseases associated with hyperphosphorylation of tau.